ArticleJournal of ginseng research2012
UPLC-Q-TOF-MS/MS Analysis for Steaming Times-dependent Profiling of Steamed Panax quinquefolius and Its Ginsenosides Transformations Induced by Repetitious Steaming.
Article in Journal of ginseng research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Pseudoginsenoside-F11: a comprehensive review of chemical structure, pharmacological activities, pharmacokinetics, and therapeutic potential.Frontiers in pharmacology · 2026Review
- Neuroprotection and Enhanced Learning and Memory Abilities of Steamed American Ginseng (Food science & nutrition · 2025Article
- Rare ginsenosides: A unique perspective of ginseng research.Journal of advanced research · 2024Review
- Mass spectrometry-based ginsenoside profiling: Recent applications, limitations, and perspectives.Journal of ginseng research · 2024Review
- Comprehensive Investigation of Ginsenosides in the SteamedMolecules (Basel, Switzerland) · 2024Article
- Screening anti-fatigue components of American ginseng saponin by analyzing spectrum-effect relationship coupled with UPLC-Q-TOF-MS.Asian biomedicine : research, reviews and news · 2023Article
- Chemical Differentiation and Quantitative Analysis of Black Ginseng Based on an LC-MS Combined with Multivariate Statistical Analysis Approach.Molecules (Basel, Switzerland) · 2023Article
- Identification and analysis of BAHD superfamily related to malonyl ginsenoside biosynthesis inFrontiers in plant science · 2023Article
- Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials.Chinese medicine · 2022Review
- UPLC-Q-TOF-MS/MS Analysis ofFrontiers in microbiology · 2022Article
- Phytochemical analysis ofJournal of ginseng research · 2021Review
- Advances in Saponin Diversity ofMolecules (Basel, Switzerland) · 2020Review
- Changes of Ginsenoside Composition in the Creation of Black Ginseng Leaf.Molecules (Basel, Switzerland) · 2020Article
- Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects.Molecules (Basel, Switzerland) · 2019Review
- Various Multicharged Anions of Ginsenosides in Negative Electrospray Ionization with QTOF High-Resolution Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- Multicomponent assessment and ginsenoside conversions ofJournal of ginseng research · 2019Article
- Depsidomycins B and C: New Cyclic Peptides from a Ginseng Farm Soil-Derived Actinomycete.Molecules (Basel, Switzerland) · 2018Article
- A new strategy for choosing "Q-markers" via network pharmacology, application to the quality control of a Chinese medical preparation.Journal of food and drug analysis · 2018Article
- Article
- Complete (1)H-NMR and (13)C-NMR spectral assignment of five malonyl ginsenosides from the fresh flower buds of Panax ginseng.Journal of ginseng research · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolic profiles of Panax quinquefolius and its associated therapeutic values are critically affected by the repetitious steaming times. The times-dependent steaming effect of P. quinquefolius is not well-characterized and there is also no official guideline on its times of steaming. In this paper, a UPLC-Q-TOF-MS/MS method was developed for the qualitative profiling of multi-parametric metabolic changes of raw P. quinquefolius during the repetitious steaming process. Our method was successful in discriminating the differentially multi-steamed herbs. Meantime, the repetitious steaming-inducing chemical transformations in the preparation of black American ginseng (American ginseng that was subjected to 9 cycles of steaming treatment) were evaluated by this UPLC-Q-TOF-MS/MS based chemical profiling method. Under the optimized UPLC-Q-TOF-MS/MS conditions, 29 major ginsenosides were unambiguously identified and/or tentatively assigned in both raw and multi-steamed P. quinquefolius within 19 min, among them 18 ginsenosides were detected to be newly generated during the preparatory process of black American ginseng. The mechanisms involved were further deduced to be hydrolysis, dehydration, decarboxylation and addition reactions of the original ginsenosides in raw P. quinquefolius through analyzing mimic 9 cycles of steaming extracts of 14 pure reference ginsenosides. Our novel steaming times-dependent metabolic profiling approach represents the paradigm shift in the global quality control of multi-steamed P. quinquefolius products.
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