ArticleJournal of ginseng research2012
Processed Panax ginseng, Sun Ginseng, Decreases Oxidative Damage Induced by tert-butyl Hydroperoxide via Regulation of Antioxidant Enzyme and Anti-apoptotic Molecules in HepG2 Cells.
Article in Journal of ginseng research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3.Molecules (Basel, Switzerland) · 2023Review
- Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells.International journal of molecular medicine · 2022Article
- Insights into the antitumor mechanism of ginsenosides Rg3.Molecular biology reports · 2021Review
- Korean Red Ginseng enhances cardiac hemodynamics on doxorubicin-induced toxicity in rats.Journal of ginseng research · 2020Article
- Ginseng for an eye: effects of ginseng on ocular diseases.Journal of ginseng research · 2020Review
- Functional Teas from the Stems of Penthorum chinense Pursh.: Phenolic Constituents, Antioxidant and Hepatoprotective Activity.Plant foods for human nutrition (Dordrecht, Netherlands) · 2019Article
- Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells.Frontiers in pharmacology · 2019Review
- Ethyl Acetate Fraction ofOxidative medicine and cellular longevity · 2018Article
- ProcessedJournal of ginseng research · 2017Article
- Cytotoxic effects of oosporein isolated from endophytic fungus Cochliobolus kusanoi.Frontiers in microbiology · 2015Article
- Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells.Journal of ginseng research · 2015Article
- Amelioration of insulin resistance by Rk1 + Rg5 complex under endoplasmic reticulum stress conditions.Pharmacognosy research · 2014Article
- Neuroprotective effects of bikaverin on H2O2-induced oxidative stress mediated neuronal damage in SH-SY5Y cell line.Cellular and molecular neurobiology · 2014Article
- Processed Vietnamese ginseng: Preliminary results in chemistry and biological activity.Journal of ginseng research · 2014Article
- Red ginseng (Panax ginseng) decreases isoproterenol-induced cardiac injury via antioxidant properties in porcine.Journal of medicinal food · 2014Article
- Korean Red Ginseng Induced Cardioprotection against Myocardial Ischemia in Guinea Pig.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- Extracellular signal-regulated kinase is a direct target of the anti-inflammatory compound amentoflavone derived from Torreya nucifera.Mediators of inflammation · 2013Article
- HangAmDan-B, an ethnomedicinal herbal mixture, suppresses inflammatory responses by inhibiting Syk/NF-κB and JNK/ATF-2 pathways.Journal of medicinal food · 2013Article
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5 authors.
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Abstract
Potential antioxidant effect of processed ginseng (sun ginseng, SG) on oxidative stress generated by tert-butyl hydroperoxide (t-BHP) was investigated in HepG2 cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and lactate dehydrogenase (LDH) leakage test demonstrated that SG dose-dependently prevents a loss of cell viability against t-BHP-induced oxidative stress. Also, SG treatment dose-dependently relieved the increment of activities of hepatic enzymes, such as aspartate aminotrasferase and alanine aminotransferase, and lipid peroxidation mediated by t-BHP treatment in HepG2 cells. SG increased the gene expression of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. However, high dose of SG treatment caused decrease in mRNA level of glutathione peroxidase as compared to low dosage of SG-treated cells. The gene expression of glutathione reductase was found to be slightly increased by SG treatment. In addition, SG extract attributed its hepaprotective effect by inducing the mRNA level of bcl-2 and bcl-xL but reducing that of bax. But, the gene expression of bad showed no significant change in SG-treated HepG2 cells. These findings suggest that SG has hepatoprotective effect by showing reduction of LDH release, activities of hepatic enzymes and lipid peroxidation and regulating the gene expression of antioxidant enzymes and apoptosis-related molecules against oxdative stress caused by t-BHP in HepG2 cells.
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