ArticleJournal of ginseng research2011
Frequent Genetic Defects in the HIV-1 5' LTR/gag Gene in Hemophiliacs Treated with Korean Red Ginseng: Decreased Detection of Genetic Defects by Highly Active Antiretroviral Therapy.
Article in Journal of ginseng research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of Korean red ginseng on the HIV-1Journal of ginseng research · 2026Article
- Aberrant strand transfer events across multiple stages of reverse transcription shape the heterogeneous landscape of the HIV-1 reservoir.Communications biology · 2025Article
- Korean Red Ginseng slows coreceptor switch in HIV-1 infected patients.Journal of ginseng research · 2023Article
- Impact of HIV-1 subtypes on gross deletion in theJournal of ginseng research · 2022Article
- The frequency of defective genes inJournal of ginseng research · 2021Article
- Korean Red Ginseng increases defectiveJournal of ginseng research · 2019Article
- Protective roles of ginseng against bacterial infection.Microbial cell (Graz, Austria) · 2018Review
- Genetic defects in theJournal of ginseng research · 2017Article
- Ginseng, the natural effectual antiviral: Protective effects of Korean Red Ginseng against viral infection.Journal of ginseng research · 2016Review
- Phylogenetic analysis of near full-length HIV type 1 genomic sequences from 21 Korean individuals.AIDS research and human retroviruses · 2013Article
- Effects of Korean Red Ginseng and HAART on vif Gene in 10 Long-Term Slow Progressors over 20 Years: High Frequency of Deletions and G-to-A Hypermutation.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System.Journal of ginseng research · 2012Article
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4 authors at 3 institutions in 1 country.
Funding
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Abstract
We investigated whether Korean red ginseng (KRG) and highly active antiretroviral therapy (HAART) affect the frequency of gross deletion in 5'LTR/gag in 20 hemophiliacs. This study is a prospective study in 20 hemophiliacs who were infected with Korean subclade B of HIV-1 from two cash-paid plasma donors in 1990. Over a 13-year period, we obtained 436 amplicons of 5'LTR/gag genes by nested polymerase chain reaction using 147 peripheral blood mononuclear cells. Of the 436 amplicons, 92 (21.1%) showed gross deletion in 5'LTR/gag. Despite of a 2.3-fold higher monthly dose of KRG intake, the frequency of gross deletion in 5'LTR/gag (16.4%) was significantly decreased during HAART compared with 28.1% prior to HAART (p<0.01). Gross deletion in 5'LTR/gag was 10% more detected on KRG-therapy than prior to KRG-therapy (p<0.05). In addition, we also obtained 28 amplicons containing premature stop codon or isoleucine at initiation codon of 254 amplicons sequenced on KRG intake (7.5%) or HAART (13.6%) compared with 0% before KRG intake. These findings indicate that high frequency of gross deletion in 5'LTR/gag and genetic defects prior to HAART are significantly associated with KRG intake and the detection of gross deletion in 5'LTR/gag is decreased by HAART.
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