ArticleAnnals of dermatology2013
Merkel cell polyomavirus is frequently detected in korean patients with merkel cell carcinoma.
Article in Annals of dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Merkel Cell Carcinoma.Biomedicines · 2021Review
- A Case of Merkel Cell Carcinoma on the Finger.Annals of dermatology · 2019Article
- No Association between Merkel Cell Polymavirus Infection and Keratoacanthoma in Korean PatientsAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Prevalence of cutaneous viral infections in incident cutaneous squamous cell carcinoma detected among chronic lymphocytic leukemia and hematopoietic stem cell transplant patients.Leukemia & lymphoma · 2018Article
- Merkel Cell Carcinoma: An Update and Immunotherapy.Frontiers in oncology · 2018Review
- Natural history of polyomaviruses in men: the HPV infection in men (HIM) study.The Journal of infectious diseases · 2015Article
- Serodiagnosis for tumor viruses.Seminars in oncology · 2015Review
- Merkel cell polyomavirus (MCV) T-antigen seroreactivity, MCV DNA in eyebrow hairs, and squamous cell carcinoma.Infectious agents and cancer · 2015Article
- Merkel cell carcinoma of the head and neck: pathogenesis, current and emerging treatment options.OncoTargets and therapy · 2015Review
- Merkel cell polyomavirus and its etiological relationship with skin tumors.Anais brasileiros de dermatologiaReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMerkel cell carcinoma (MCC) is an increasingly common neuroendocrine cancer of the skin. Merkel cell polyomavirus (MCPyV) is one of the causative agents of MCC. The prevalence of MCPyV in primary MCC and sun-exposed non-MCC tumors has been known to have different results depending on where it was investigated.
objectiveThis study assesses the prevalence of MCPyV from primary MCC and sun-exposed non-MCC tumors in Korea.
methodsA molecular pathology study was performed on 7 tissue specimens of MCC, 1 tissue specimen of metastatic small cell carcinoma of the lung, and 32 tissue specimens of non-MCC tumors occurring from sun-exposed areas [8 basal cell carcinomas (BCCs), 8 squamous cell carcinomas (SCCs), 8 actinic keratoses (AKs), and 8 seborrheic keratoses (SKs)]. All specimens were analyzed to determine the presence of MCPyV-DNA using both polymerase chain reaction (PCR) and real-time quantitative PCR. Immunohistochemistry with monoclonal antibody of MCPyV large T antigen (CM2B4) was also conducted.
resultsUsing both PCR, MCPyV sequences were detected in six of seven MCC tissue specimens (85.7%). Five (71%) of seven MCC tumors were immunoreactive for CM2B4. All five immunoreactive cases were positive for MCPyV. However, there was no association of MCPyV with BCC, SCC, AK, and SK.
conclusionOur results implicate that MCPyV may contribute to the pathogenesis of primary MCC, not of non-MCC skin tumors in Korea, and the persons with MCPyV infection are unusual in Korea compared to other areas.
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