Trial reportWorld journal of gastroenterology2013
Glucomannan for abdominal pain-related functional gastrointestinal disorders in children: a randomized trial.
Trial report in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03639142 (Dried Plums), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dried Plums (Prunes) vs. Polyethylene Glycol 4000 for Treatment of Functional Constipation in Children - Randomised Controlled Trial
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- ESPGHAN/NASPGHAN guidelines for treatment of irritable bowel syndrome and functional abdominal pain-not otherwise specified in children aged 4-18 years.Journal of pediatric gastroenterology and nutrition · 2025Guideline
- Dietary interventions for pediatric patients with functional abdominal pain disorders: a systematic review and network meta-analysis.European journal of pediatrics · 2023Pooled it
- Dietary interventions for recurrent abdominal pain in childhood.The Cochrane database of systematic reviews · 2017Pooled it
- Randomized Placebo-Controlled Trial of Psyllium Fiber in Functional Abdominal Pain Disorders in Children.Digestive diseases and sciences · 2026Trial
- Review
- Dietary fiber in pediatric gastrointestinal health: a narrative review of evidence and challenges.Clinical and experimental pediatrics · 2026Review
- Navigating through 65 years of insights: lessons learned on functional abdominal pain in children.European journal of pediatrics · 2024Review
- Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights.Nutrients · 2024Review
- The Use of Fibers, Herbal Medicines and Spices in Children with Irritable Bowel Syndrome: A Narrative Review.Nutrients · 2023Review
- The benefits of dietary fiber: the gastrointestinal tract and beyond.Pediatric nephrology (Berlin, Germany) · 2023Review
- Dietary Fibers in Healthy Children and in Pediatric Gastrointestinal Disorders: A Practical Guide.Nutrients · 2023Review
- Non-pharmacologic approaches to treatment of pediatric functional abdominal pain disorders.Frontiers in pediatrics · 2023Review
- The Mediterranean Diet in Paediatric Gastrointestinal Disorders.Nutrients · 2022Review
- Nutritional Aspects of Pediatric Gastrointestinal Diseases.Nutrients · 2021Review
- An Update on the Assessment and Management of Pediatric Abdominal Pain.Pediatric health, medicine and therapeutics · 2021Review
- Functional abdominal pain in adolescents: case-based management.Frontline gastroenterology · 2021Article
- Challenging the view that lack of fibre causes childhood constipation.Archives of disease in childhood · 2020Article
- Update on Dietary Management of Childhood Functional Abdominal Pain Disorders.Gastroenterology clinics of North America · 2018Review
- Irritable bowel syndrome in children: Current knowledge, challenges and opportunities.World journal of gastroenterology · 2018Review
- Childhood functional abdominal pain: mechanisms and management.Nature reviews. Gastroenterology & hepatology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the efficacy of glucomannan (GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders (FGIDs).
methodsWe conducted a double-blind, placebo-controlled, randomized trial. Patients were recruited among children referred to the Department of Paediatrics, Medical University of Warsaw. Included in the study were children aged 7-17 years with abdominal pain-related FGIDs classified according to the Rome III diagnostic criteria. The children were randomly assigned to receive GNN, a polysaccharide of 1,4-D-glucose and D-mannose, a soluble fiber from the Japanese Konjac plant, at a dosage of 2.52 g/d (1 sachet of 1.26 g 2 times a day), or a comparable placebo (maltodextrin) at the same dosage. The content of each sachet was dissolved in approximately 125 mL of fluid and was consumed twice daily for 4 wk.
resultsOf the 89 eligible children, 84 (94%) completed the study. "No pain" and "treatment success" (defined as no pain or a decrease ≥ 2/6 points on the FACES Pain Scale Revised) were similar in the GNN (n = 41) and placebo (n = 43) groups [no pain (12/41 vs 6/43, respectively; RR = 2.1, 95%CI: 0.87-5.07) as well as treatment success (23/41 vs 20/43; RR = 1.2, 95%CI: 0.79-1.83)]. No significant differences between the groups were observed in the secondary outcomes, such as abdominal cramps, abdominal bloating/gassiness, episodes of nausea or vomiting, or a changed in stool consistency. GNN demonstrated no significant influence on the number of children requiring rescue therapy, school absenteeism, or daily activities.
conclusionIn our setting, GNN, as dosed in this study, was no more effective than the placebo in achieving therapeutic success in the management of FGIDs in children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.