ArticleIndian journal of pharmaceutical sciences2012
Intestinal permeability of Lamivudine using single pass intestinal perfusion.
Article in Indian journal of pharmaceutical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Comparative evaluation of dissolution profiles of the generic drug lamivudine 150 mg tablet marketed in Peru vs. the innovative Epivir.Revista peruana de medicina experimental y salud publica · 2024Article
- In Silico Prediction of Intestinal Permeability by Hierarchical Support Vector Regression.International journal of molecular sciences · 2020Article
- Development and In Vivo Evaluation of Ziyuglycoside I-Loaded Self-Microemulsifying Formulation for Activity of Increasing Leukocyte.AAPS PharmSciTech · 2019Article
- Mucus models to evaluate the diffusion of drugs and particles.Advanced drug delivery reviews · 2018Review
- Study of Absorption Characteristics of the Total Saponins from Radix Ilicis Pubescentis in an In Situ Single-Pass Intestinal Perfusion (SPIP) Rat Model by Using Ultra Performance Liquid Chromatography (UPLC).Molecules (Basel, Switzerland) · 2017Article
- Inhibitory effect of clemastine on P-glycoprotein expression and function: an in vitro and in situ study.Iranian journal of basic medical sciences · 2016Article
- The Effects of Cetirizine on P-glycoprotein Expression and Function In vitro and In situ.Advanced pharmaceutical bulletin · 2016Article
- Effects of fructus psoraleae extract on the intestinal absorption kinetics of geniposide and geniposidic acid in rat.Molecules (Basel, Switzerland) · 2014Article
- Inhibition of P-glycoprotein expression and function by anti-diabetic drugs gliclazide, metformin, and pioglitazone in vitro and in situ.Research in pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal transport of lamivudine, a nucleotide reverse transcriptase inhibitor, was investigated using the single pass intestinal perfusion technique in male Wistar rats. Single pass intestinal perfusion was performed in small intestine at a flow rate of 0.20 ml/min. Lamivudine exhibits a high intestinal permeability over the length of the small intestine indicative of compounds that are well absorbed. The P eff of lamivudine is in the range of drugs with high intestinal permeability and high fraction of dose absorbed indicating that lamivudine readily crosses the intestine. This also suggests that lamivudine belongs to biopharmaceutics classification system class I and is a good candidate for biopharmaceutics classification system based biowaiver. The permeability values obtained from this study may be useful in models of exposure assessment.
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Registered trials
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