ArticleSchizophrenia bulletin2013
Epidemiological and clinical characterization following a first psychotic episode in major depressive disorder: comparisons with schizophrenia and bipolar I disorder in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS).
Article in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Meta-analysis of Cognitive Impairment in First-Episode Bipolar Disorder: Comparison With First-Episode Schizophrenia and Healthy Controls.Schizophrenia bulletin · 2015Pooled it
- Gender differences and risk factors for suicide attempts in first-episode drug-naïve psychotic versus non-psychotic major depression: a large cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Two Sides of One Coin: Affective Psychosis vs. Non-Affective Psychosis in Teenagers.Children (Basel, Switzerland) · 2026Article
- Overlapping pathogenic de novo CNVs in neurodevelopmental disorders and congenital anomalies impacting constraint genes regulating early development.Human genetics · 2023Article
- Correlates of neurological soft signs in bipolar disorder.European archives of psychiatry and clinical neuroscience · 2023Article
- Ketamine as Add-On Treatment in Psychotic Treatment-Resistant Depression.Brain sciences · 2023Article
- Psychotic symptoms in bipolar disorder and their impact on the illness: A systematic review.World journal of psychiatry · 2022Article
- Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects.Journal of clinical medicine · 2022Article
- Depression and Psychosis Risk Shared Vulnerability for Motor Signs Across Development, Symptom Dimensions, and Familial Risk.Schizophrenia bulletin · 2022Article
- The neural substrates of neurological soft signs in schizophrenia: a systematic review.Schizophrenia (Heidelberg, Germany) · 2022Review
- Clinical Approaches to Late-Onset Psychosis.Journal of personalized medicine · 2022Review
- Motor abnormalities, depression risk, and clinical course in adolescence.Biological psychiatry global open science · 2022Article
- Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.Translational psychiatry · 2021Article
- Using Two-Step Cluster Analysis and Latent Class Cluster Analysis to Classify the Cognitive Heterogeneity of Cross-Diagnostic Psychiatric Inpatients.Frontiers in psychology · 2020Article
- Psychotic disorders in late life: a narrative review.Therapeutic advances in psychopharmacology · 2019Review
- Emerging and evolving concepts in the pathobiology and treatment of psychosis.CNS neuroscience & therapeutics · 2018Article
- Functional outcome and service engagement in major depressive disorder with psychotic features: comparisons with schizophrenia, schizoaffective disorder and bipolar disorder in a 6-year follow-up of the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS).CNS neuroscience & therapeutics · 2018Article
- Motor System Pathology in Psychosis.Current psychiatry reports · 2017Review
- Motor Abnormalities: From Neurodevelopmental to Neurodegenerative Through "Functional" (Neuro)Psychiatric Disorders.Schizophrenia bulletin · 2017Review
- Regressing to Prior Response Preference After Set Switching Implicates Striatal Dysfunction Across Psychotic Disorders: Findings From the B-SNIP Study.Schizophrenia bulletin · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While recent research on psychotic illness has focussed on the nosological, clinical, and biological relationships between schizophrenia and bipolar disorder, little attention has been directed to the most common other psychotic diagnosis, major depressive disorder with psychotic features (MDDP). As this diagnostic category captures the confluence between dimensions of psychotic and affective psychopathology, it is of unappreciated heuristic potential to inform on the nature of psychotic illness. Therefore, the epidemiology and clinical characteristics of MDDP were compared with those of schizophrenia and bipolar disorder within the Cavan-Monaghan First Episode Psychosis Study (n = 370). Epidemiologically, the first psychotic episode of MDDP (n = 77) was uniformly distributed across the adult life span, while schizophrenia (n = 73) and bipolar disorder (n = 73) were primarily disorders of young adulthood; the incidence of MDDP, like bipolar disorder, did not differ between the sexes, while the incidence of schizophrenia was more common in males than in females. Clinically, MDDP was characterized by negative symptoms, executive dysfunction, neurological soft signs (NSS), premorbid intellectual function, premorbid adjustment, and quality of life similar to those for schizophrenia, while bipolar disorder was characterized by less prominent negative symptoms, executive dysfunction and NSS, and better quality of life. These findings suggest that what we currently categorize as MDDP may be more closely aligned with other psychotic diagnoses than has been considered previously. They indicate that differences in how psychosis is manifested vis-à-vis depression and mania may be quantitative rather than qualitative and occur within a dimensional space, rather than validating categorical distinctions.
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Registered trials
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