ArticleMolecular and cellular biology2013
Telomere length influences cancer cell differentiation in vivo.
Article in Molecular and cellular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- Interleukin-4 induced 1-mediated resistance to an immune checkpoint inhibitor through suppression of CD8Cancer science · 2024Article
- The dynamics of telomere length in primary and metastatic colorectal cancer lesions.Scientific reports · 2023Article
- An Update to Hallmarks of Cancer.Cureus · 2022Review
- TElomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancer.Frontiers in oncology · 2022Review
- Neutralization of the induced VEGF-A potentiates the therapeutic effect of an anti-VEGFR2 antibody on gastric cancer in vivo.Scientific reports · 2021Article
- G-quadruplex-forming nucleic acids interact with splicing factor 3B subunit 2 and suppress innate immune gene expression.Genes to cells : devoted to molecular & cellular mechanisms · 2021Article
- Does Subtelomeric Position of COMMD5 Influence Cancer Progression?Frontiers in oncology · 2021Article
- Mechanobiological Implications of Cancer Progression in Space.Frontiers in cell and developmental biology · 2021Review
- Review
- Crossroads of telomere biology and anticancer drug discovery.Cancer science · 2020Review
- Review
- From the wings to the center stage of chromosomes.The Journal of biological chemistry · 2019Article
- Recent advances of Blood telomere length (BTL) shortening: A potential biomarker for development of cancer.Pathology oncology research : POR · 2019Article
- Revisiting Telomere Shortening in Cancer.Cells · 2019Review
- Influence of donor liver telomere and G-tail on clinical outcome after living donor liver transplantation.PloS one · 2019Article
- Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends.PLoS genetics · 2018Article
- Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.Scientific reports · 2018Article
- Review
- Mutations, Cancer and the Telomere Length Paradox.Trends in cancer · 2017Review
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Limitless reproductive potential is one of the hallmarks of cancer cells. This ability is due to the maintenance of telomeres, erosion of which causes cellular senescence or death. While most cancer cells activate telomerase, a telomere-elongating enzyme, it remains elusive as to why cancer cells often maintain shorter telomeres than the cells in the surrounding normal tissues. Here, we show that forced telomere elongation in cancer cells promotes their differentiation in vivo. We elongated the telomeres of human prostate cancer cells that possess short telomeres by enhancing their telomerase activity. The resulting cells had long telomeres and retained the ability to form tumors in nude mice. Strikingly, these tumors exhibited many duct-like structures and reduced N-cadherin expression, reminiscent of well-differentiated adenocarcinoma. These changes were caused by telomere elongation and not by enhanced telomerase activity. Gene expression profiling revealed that tumor formation was accompanied by the expression of innate immune system-related genes, which have been implicated in maintaining tumor cells in an undifferentiated state and poor-prognosis cancers. In tumors derived from the telomere-elongated cells, upregulation of such gene sets is not observed. Our observations suggest a functional contribution of short telomeres to tumor malignancy by regulation of cancer cell differentiation.
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