ArticleLa Radiologia medica2013
Myocardial oedema as the sole marker of acute injury in Takotsubo cardiomyopathy: a cardiovascular magnetic resonance (CMR) study.
Article in La Radiologia medica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Critical Reappraisal of Takotsubo Syndrome (TS) and Myocarditis Association: "The Myocarditis-Like Features" Seen in TS Are Secondary Changes and not True Myocarditis.Reviews in cardiovascular medicine · 2026Review
- An Extensive Review on Imaging Diagnosis Methods in Takotsubo Syndrome.Reviews in cardiovascular medicine · 2023Review
- Inflammatory Forms of Cardiomyocyte Cell Death in the Rat Model of Isoprenaline-Induced Takotsubo Syndrome.Biomedicines · 2023Article
- The Immunology of Takotsubo Syndrome.Frontiers in immunology · 2023Review
- Isoprenaline induced Takotsubo syndrome: Histopathological analyses of female rat hearts.Cardiology journal · 2022Article
- Role of advanced imaging in COVID-19 cardiovascular complications.Insights into imaging · 2021Review
- Takotsubo Syndrome: Clinical Manifestations, Etiology and Pathogenesis.Current cardiology reviews · 2021Article
- Cardiac MRI: technical basis.La Radiologia medica · 2020Review
- Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy.JACC. Basic to translational science · 2018Article
- Basal wall hypercontraction of Takotsubo cardiomyopathy in a patient who had been diagnosed with dilated cardiomyopathy: a case report.BMC cardiovascular disorders · 2017Article
- Article
- Lights and shadows of cardiac magnetic resonance imaging in acute myocarditis.Insights into imaging · 2016Article
- Diagnostic value of contrast-enhanced cardiac magnetic resonance in patients with acute coronary syndrome with normal coronary arteries.Japanese journal of radiology · 2015Article
- TakoTsubo cardiomyopathy: unravelling the malignant consequences of a benign disease with cardiac magnetic resonance.Heart failure reviews · 2015Review
- Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy.Journal of the American Heart Association · 2014Article
- Role of cardiac magnetic resonance in the evaluation of dilated cardiomyopathy: diagnostic contribution and prognostic significance.ISRN radiology · 2014Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe main hallmark of Takotsubo cardiomyopathy (TT-CMP) is transient ischaemia, with completely reversible regional contractile dysfunction, which involves the mid-apical segments and shows no angiographic signs of coronary artery disease (CAD). The acute and reversible myocardial injury suggests that tissue oedema may be an important marker of disease. MATERIALS AND
methodsSeventeen patients with a clinical and angiographic diagnosis of TT-CMP underwent cardiovascular magnetic resonance (CMR) imaging in the acute phase and at follow-up after 4 months. A standard acquisition protocol including turbo spin echo (TSE) T2-weighted short-tau inversion-recovery (T2 STIR), steady-state free-precession cine (SSFP cine) and lateenhancement (LE) imaging after gadolinium benzyloxypropionic tetraacetic acid (Gd-BOPTA) administration was performed. All images were analysed, and data on oedema and LE were correlated with regional dysfunction and histological findings from endomyocardial biopsy (EMB) where available.
resultsIn all patients, T2 STIR images showed a diffuse homogeneous hyperintensity that extended to all mid-apical segments and perfectly matched the area of regional dysfunction, reflecting tissue oedema. In the five patients who underwent EMB, histology confirmed the massive interstitial oedema associated with typical contraction-band necrosis. No cases of LE were observed. At follow-up, complete regression of oedema was observed in all cases, with significant recovery of regional and global left ventricular (LV) function (ejection fraction from 48.7% to 59.8%).
conclusionsMyocardial oedema on CMR is a characteristic feature of acute TT-CMP, which reflects acute inflammation and acute myocardial injury. It could therefore be used as a specific marker of disease severity.
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