ArticleMolecular and cellular biochemistry2013
Identification of microRNAs involved in dexamethasone-induced muscle atrophy.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- miR-708-5p Regulates Myoblast Proliferation and Differentiation.Veterinary sciences · 2022Article
- Effects of American wild ginseng and Korean cultivated wild ginseng pharmacopuncture extracts on the regulation of C2C12 myoblasts differentiation through AMPK and PI3K/Akt/mTOR signaling pathway.Molecular medicine reports · 2022Article
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- miRNAs as markers for the development of individualized training regimens: A pilot study.Physiological reports · 2022Article
- Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner.American journal of physiology. Endocrinology and metabolism · 2022Article
- H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors.Journal of cachexia, sarcopenia and muscle · 2021Article
- Role of miRNAs and lncRNAs in dexamethasone-induced myotube atrophyExperimental and therapeutic medicine · 2021Article
- MiR-147: Functions and Implications in Inflammation and Diseases.MicroRNA (Shariqah, United Arab Emirates) · 2021Review
- MicroRNA‑23a‑5p mediates the proliferation and differentiation of C2C12 myoblasts.Molecular medicine reports · 2020Article
- Role of microRNA in muscle regeneration and diseases related to muscle dysfunction in atrophy, cachexia, osteoporosis, and osteoarthritis.Bone & joint research · 2020Article
- Role of membrane-embedded drug efflux ABC transporters in the cancer chemotherapy.Oncology reviews · 2020Article
- MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by TargetingInternational journal of molecular sciences · 2020Article
- MicroRNA-mRNA Co-sequencing Identifies Transcriptional and Post-transcriptional Regulatory Networks Underlying Muscle Wasting in Cancer Cachexia.Frontiers in genetics · 2020Article
- miR-708-5p and miR-34c-5p are involved in nNOS regulation in dystrophic context.Skeletal muscle · 2018Article
- Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia.Scientific reports · 2017Article
- miR-29b contributes to multiple types of muscle atrophy.Nature communications · 2017Article
- Article
- MicroRNA-351 inhibits denervation-induced muscle atrophy by targeting TRAF6.Experimental and therapeutic medicine · 2016Article
- A novel in vitro model of sarcopenia using BubR1 hypomorphic C2C12 myoblasts.Cytotechnology · 2016Article
- Glucocorticoids Alter CRTC-CREB Signaling in Muscle Cells: Impact on PGC-1α Expression and Atrophy Markers.PloS one · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs), a novel class of post-transcriptional gene regulators, have been demonstrated to be involved in several cellular processes regulating the expression of protein-coding genes. To investigate the mechanisms of miRNA-mediated regulation during the process of muscle atrophy, we performed miRNA microarray hybridization between normal differentiated C2C12 cells and dexamethasone (DEX)-treated C2C12 cells. We observed that 11 miRNAs were significantly up-regulated and six miRNAs were down-regulated in the differentiated C2C12 cells after being treated with DEX. Stem-loop real-time RT-PCR confirmed the differential expression of six selected miRNAs (miR-1, miR-147, miR-322, miR-351, and miR-503*, miR-708). miRNA potential target prediction was accomplished using TargetScan, and many target genes related to muscle growth and atrophy have been reported in previous studies. The results of the current study suggested the potential roles of these differentially expressed miRNAs in skeletal muscle atrophy.
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