ArticleAntimicrobial agents and chemotherapy2013
Two multidrug-resistant clinical isolates of Bacteroides fragilis carry a novel metronidazole resistance nim gene (nimJ).
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Proteomics-Based RT-qPCR and Functional Analysis of 18 Genes in Metronidazole Resistance ofAntibiotics (Basel, Switzerland) · 2024Article
- Creep in nitroimidazole inhibitory concentration among the Entamoeba histolytica isolates causing amoebic liver abscess and screening of andrographolide as a repurposing drug.Scientific reports · 2023Article
- Recent Trends in Antimicrobial Resistance among Anaerobic Clinical Isolates.Microorganisms · 2023Review
- Antibiotic Resistance and Mechanisms of Pathogenic Bacteria in Tubo-Ovarian Abscess.Frontiers in cellular and infection microbiology · 2022Review
- Characterization of Metronidazole-ResistantFrontiers in microbiology · 2022Article
- Review
- Complete hybrid genome assembly of clinical multidrug-resistantMicrobial genomics · 2019Article
- Three metronidazole-resistant Prevotella bivia strains harbour a mobile element, encoding a novel nim gene, nimK, and an efflux small MDR transporter.The Journal of antimicrobial chemotherapy · 2018Article
- Novel large-scale chromosomal transfer in Bacteroides fragilis contributes to its pan-genome and rapid environmental adaptation.Microbial genomics · 2017Article
- A Novel Selective Medium for Isolation of Bacteroides fragilis from Clinical Specimens.Journal of clinical microbiology · 2017Article
- Water Sources in a Zoological Park Harbor Genetically Diverse Strains of Clostridium Perfringens Type A with Decreased Susceptibility to Metronidazole.Microbial ecology · 2016Article
- Antimicrobial Resistance and Reduced Susceptibility in Clostridium difficile: Potential Consequences for Induction, Treatment, and Recurrence of C. difficile Infection.Antibiotics (Basel, Switzerland) · 2015Review
- Characterization of a multidrug-resistant, novel Bacteroides genomospecies.Emerging infectious diseases · 2015Article
- Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis.The Journal of antimicrobial chemotherapy · 2014Article
- Identification of genes required for the survival of B. fragilis using massive parallel sequencing of a saturated transposon mutant library.BMC genomics · 2014Article
- A study on Nim expression in Bacteroides fragilis.Microbiology (Reading, England) · 2014Article
- The Ellis Island Effect: A novel mobile element in a multi-drug resistantMobile genetic elements · 2014Article
- Antimicrobial Resistance Profile andJournal of global infectious diseasesArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Two multidrug-resistant Bacteroides fragilis clinical isolates contain and express a novel nim gene, nimJ, that is not recognized by the "universal" nim primers and can confer increased resistance to metronidazole when introduced into a susceptible strain on a multicopy plasmid. HMW615, an appendiceal isolate, contains at least two copies of nimJ on its genome, while HMW616, an isolate from a patient with sepsis, contains one genomic copy of nimJ. B. fragilis NimJ is phylogenetically closer to Prevotella baroniae NimI and Clostridium botulinum NimA than to the other known Bacteroides Nim proteins. The predicted protein structure of NimJ, based on fold recognition analysis, is consistent with the crystal structures derived for known Nim proteins, and specific amino acid residues important for substrate binding in the active site are conserved. This study demonstrates that the "universal" nim primers will not detect all nim genes with the ability to confer metronidazole resistance, but nimJ alone cannot account for the very high metronidazole MICs of these resistant clinical isolates.
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