Evidence map›Paper›PMID 23716043›Full record

ArticleAntimicrobial agents and chemotherapy2013

Nationwide surveillance of macrolide-resistant Mycoplasma pneumoniae infection in pediatric patients.

Yasuhiro Kawai, Naoyuki Miyashita, Mika Kubo, Hiroto Akaike, Atsushi Kato, Yoko Nishizawa, Aki Saito, Eisuke Kondo, Hideto Teranishi, Tokio Wakabayashi and 6 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04126304 (Multi-center Investigation and Study of Mycoplasma Pneumoniae Infection and Macrolide Drug Resistance in Outpatient and In-hospital Pediatric Acute Respiratory Diseases Illness in China), which is not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04126304 unknown statusnot on this mapstarted 2019, after this paper: background citation

Multi-center Investigation and Study of Mycoplasma Pneumoniae Infection and Macrolide Drug Resistance in Outpatient and In-hospital Pediatric Acute Respiratory Diseases Illness in China

TypeobservationalSponsorShanghai Children's Medical CenterRan2019 to 2021Enrolled2,312ConditionsRespiratory Tract InfectionsArmsAzithromycin, non-macrolides antibiotics, Mycoplasma detection, Data collection
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Efficacy of garenoxacin in patients with macrolide-resistantAntimicrobial agents and chemotherapy · 2026
    Article
  6. Article
  7. Clinical features and risk factors for severe macrolide-resistant mycoplasma pneumoniae pneumonia induced by 23 S rRNA A2063G mutation: a retrospective observational study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Observational
  8. Article
  9. Article
  10. Article
  11. Novel mechanisms of macrolide resistance revealed byFrontiers in cellular and infection microbiology · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Clinical Significance of Pleural Effusion inPathogens (Basel, Switzerland) · 2021
    Article
  17. Article
  18. Article
  19. Increased Macrolide Resistance Rate of M3562Frontiers in cellular and infection microbiology · 2021
    Article
  20. The Prevalence ofReports of biochemistry & molecular biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yasuhiro KawaiDepartment of Pediatrics, Kawasaki Medical School, Okayama, Japan.
Naoyuki Miyashita
Mika Kubo
Hiroto Akaike
Atsushi Kato
Yoko Nishizawa
Aki Saito
Eisuke Kondo
Hideto Teranishi
Tokio Wakabayashi
Satoko Ogita
Takaaki Tanaka
Kozo Kawasaki
Takashi Nakano
Kihei Terada
Kazunobu Ouchi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted nationwide surveillance to investigate regional differences in macrolide-resistant (MR) Mycoplasma pneumoniae strains in Japan. The prevalence of MR M. pneumoniae in pediatric patients gradually increased between 2008 and 2012. Although regional differences were observed, high levels of MR genes were detected in all seven surveillance areas throughout Japan and ranged in prevalence from 50% to 93%. These regional differences were closely related to the previous administration of macrolides.

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsAnti-Infective AgentsChildErythromycinHumansJapanMicrobial Sensitivity TestsMutationMycoplasma pneumoniaePneumonia, MycoplasmaPrevalenceRespiratory Tract InfectionsAnti-Bacterial AgentsAnti-Infective AgentsErythromycin

Identifiers

PMID23716043
PMCPMC3719750

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.