ArticleInternational journal of legal medicine2014
Markers of mechanical asphyxia: immunohistochemical study on autoptic lung tissues.
Article in International journal of legal medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- State-of-the-Art on Wound Vitality Evaluation: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- A Comparative Analysis of the Efficacy of CD117 and Special Stains as Indicators of Mechanical Asphyxial Deaths.Annals of African medicine · 2026Article
- Death by hanging: possibilities and limits of medico-legal evidence.International journal of legal medicine · 2026Review
- Combined machine learning identification and experimental validation of NDUFS8 and SUCLG1 as potential biomarkers for mechanical asphyxia.Frontiers in medicine · 2026Article
- The application of neutrophil extracellular traps to thrombus age Estimation in rat deep vein thrombosis model.Forensic science, medicine, and pathology · 2025Article
- Exploring Potential Diagnostic Biomarkers for Mechanical Asphyxia in the Heart Based on Proteomics Technology.International journal of molecular sciences · 2024Article
- Post Mortem Molecular Biomarkers of Asphyxia: A Literature Review.International journal of molecular sciences · 2024Review
- The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review.International journal of molecular sciences · 2024Review
- Relationship between intrathrombotic appearance of HSP27 and HSP70 and thrombus ages in a murine model of deep vein thrombosis.Scientific reports · 2023Article
- Lethal nitrous oxide (NJournal of medical case reports · 2023Article
- The potential of using non-coding RNAs in forensic science applications.Forensic sciences research · 2023Review
- Combining Oxidative Stress Markers and Expression of Surfactant Protein A in Lungs in the Diagnosis of Seawater Drowning.Life (Basel, Switzerland) · 2023Article
- Article
- Cause of Death in Charred Bodies: Reflections and Operational Insights Based on a Large Cases Study.Diagnostics (Basel, Switzerland) · 2022Article
- ER stress-related protein, CHOP, may serve as a biomarker of mechanical asphyxia: a primary study.International journal of legal medicine · 2022Article
- Acute or chronic pulmonary emphysema? Or both?-A contribution to the diagnosis of death due to violent asphyxiation in cases with pre-existing chronic emphysema.International journal of legal medicine · 2022Article
- Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model.Scientific reports · 2021Article
- Intrathrombotic appearances of AQP-1 and AQP-3 in relation to thrombus age in murine deep vein thrombosis model.International journal of legal medicine · 2021Article
- Immunohistochemical expression of P-selectin, SP-A, HSP70, aquaporin 5, and fibronectin in saltwater drowning and freshwater drowning.International journal of legal medicine · 2019Article
- Cytoplasmic upregulation of Cyto c and AIF serve as biomarkers of mechanical asphyxia death.American journal of translational research · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Forensic pathologists are often asked to provide evidence of asphyxia death in the trial and a histological marker of asphyxiation would be of great help. Data from the literature indicate that the reaction of lung tissue cells to asphyxia may be of more interest for forensic purposes than migrating cells. The lungs of 62 medico-legal autopsy cases, 34 acute mechanical asphyxia (AMA), and 28 control cases (CC), were immunostained with anti-P-selectin, anti-E-selectin, anti-SP-A, and anti-HIF1-α antibodies, in order to verify if some of them may be used as markers of asphyxia death. Results show that P- and E-selectins expression in lung vessels, being activated by several types of trigger stimuli not specific to hypoxia, cannot be used as indicator of asphyxia. Intra-alveolar granular deposits of SP-A seem to be related to an intense hypoxic stimulus, and when massively present, they can suggest, together with other elements, a severe hypoxia as the mechanism of death. HIF1-α was expressed in small-, medium-, and large-caliber lung vessels of the vast majority of mechanical asphyxia deaths and CO intoxications, with the number and intensity of positive-stained vessels increasing with the duration of the hypoxia. Although further confirmation studies are required, these preliminary data indicate an interesting potential utility of HIF1-α as a screening test for asphyxia deaths.
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