ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2013
Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Post-operative events following elective craniotomy for tumor in children.Journal of neuro-oncology · 2025Article
- Pediatric hemispheric cerebellar low-grade gliomas: clinical approach, diagnosis, and management challenges-experience at a tertiary care children's hospital.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Observational
- Neurosurgical treatment of pediatric brain tumors - results from a single center multidisciplinary setup.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Cerebellar pilocytic astrocytoma. Retrospective cohort study assessing postoperative functional outcome, cerebellar mutism and hydrocephalus.World neurosurgery: X · 2023Article
- Predicting postoperative tracheostomy requirement in children undergoing surgery for posterior fossa tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Predicting dysphagia in children undergoing surgery for posterior fossa tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Pediatric cerebellar pilocytic astrocytoma presenting with spontaneous intratumoral hemorrhage.Neurosurgical review · 2020Review
- Pediatric cerebellar astrocytoma: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Review
- Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study.Oncology letters · 2015Article
- Impairments that influence physical function among survivors of childhood cancer.Children (Basel, Switzerland) · 2015Article
- Anorexia: an early sign of fourth ventricle astrocytoma in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Advances in the management of low-grade gliomas.Current oncology reports · 2014Review
- The Satisfactory Surgical Outcome of Posterior Fossa Brain Tumors in Children at Civil Hospital, Karachi.Asian journal of neurosurgeryArticle
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Authors and funding
7 authors.
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Abstract
backgroundReview of children with low-grade cerebellar astrocytoma (LGCA) prior to 1992 showed a 98% rate of gross total resection (GTR) but a concerning incidence of permanent neurological dysfunction. The purpose of this study was to determine the rate of GTR of LGCA since 1992 and frequency of neurologic injury.
methodsRetrospective review of children with LGCA was performed. CT/MR scans were rereviewed to assess extent of resection. Primary outcomes included incidence of GTR and incidence of permanent new neurological deficits. Other outcomes included late effects severity score (LESS), Bloom score for functional status, and educational assessment.
resultsOf 50 LGCA, GTR was achieved in 38 (76%) compared to 43 of 44 (98%) prior to 1992 (p < 0.004). Permanent new neurologic deficits from surgery occurred in 16% compared to 18% in the prior era (p = 0.61). For 35 patients operated on by the 2 surgeons in the prior study, 74% had GTR, with permanent neurological deficits in 8.6%. At latest follow-up, all patients were alive, 16% with residual tumor. LESS was two or less (mild or no deficit) in 94%. Bloom score was one or two (no or mild disability) in 90%. Eighty-six percent attended normal school.
conclusionsLess aggressive resection of LGCA in children may reduce postoperative neurologic deficits in the hands of the same surgeons as in the prior study but not overall at our institution. The good long-term outcomes suggest that it may be appropriate to do incomplete resection rather than risk additional neurological deficit.
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