ReviewIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2013
Pediatric and adult celiac disease: similarities and differences.
Review in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Classical celiac disease is more frequent with a double dose of HLA-DQB1*02: A systematic review with meta-analysis.PloS one · 2019Pooled it
- Generalisability of an adult-trained AI model to paediatric coeliac disease diagnosis: a multicentre external validation study.EClinicalMedicine · 2026Article
- Challenges in the Pediatric Celiac Disease Diagnosis: An Up-to-Date Review.Diagnostics (Basel, Switzerland) · 2025Review
- Evaluation of Frequency of Celiac Disease in Children with Idiopathic Epilepsy.Iranian journal of child neurology · 2024Article
- Nutritional Status of Saudi Children with Celiac Disease Following the Ministry of Health's Gluten-Free Diet Program.Nutrients · 2022Article
- Comparison of Endoscopic and Histological Findings between Typical and Atypical Celiac Disease in Children.Pediatric gastroenterology, hepatology & nutrition · 2018Article
- Palivizumab Exposure and the Risk of Autoimmune Disease: A Cross-National Cohort Study.Paediatric drugs · 2016Article
- Article
- Article
- What a practitioner needs to know about celiac disease?Indian journal of pediatrics · 2015Review
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Differences between children and adults in celiac disease (CD) presentation and epidemiology are reviewed here. Clinical manifestations, histological changes, serology, and response to gluten-free diet are similar. Differences exist in epidemiology, type of clinical presentations, coexisting diseases, complications, and association with obesity. CD is two to five times more common in children than in adults. Classical CD with gastrointestinal symptoms is more common in children whereas nonclassical CD dominates in adults. A gene dose phenomenon (double-dose HLA-DQB1 02 allele) is postulated to be responsible for this difference. Coexisting autoimmune diseases like diabetes mellitus type 1, Sjogren's syndrome, and dermatitis herpetiformis are more common in adults than in children (42 % vs. 5 %). The association of overweight/obesity and CD is stronger in adults than in children (22.5 % vs. 14 %). Besides poor compliance, pancreatic insufficiency, bacterial overgrowth, lactose intolerance, irritable bowel syndrome, lymphocytic colitis, and microscopic colitis are considered responsible for nonresponsive CD in adults but not in children. Complications like refractory sprue and small intestinal neoplasms are seen exclusively in adults. Existing diagnostic criteria (modified ESPGHAN) are not suitable for diagnosing CD in adults as the majority of cases are either nonclassical or subclinical CD.
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