Evidence map›Paper›PMID 23715550›Full record

ReviewDevelopment (Cambridge, England)2013

Stem cells in retinal regeneration: past, present and future.

Conor M Ramsden, Michael B Powner, Amanda-Jayne F Carr, Matthew J K Smart, Lyndon da Cruz, Peter J Coffey

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 1 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 1 synthesis or guideline pooled it, 256 citations in OpenAlex.

  1. Pooled it
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  7. Article
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  11. Human iPS Cells for Clinical Applications and Cellular Products.Handbook of experimental pharmacology · 2023
    Article
  12. Review
  13. Article
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  16. Review
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  18. Article
  19. Retina stem cells, hopes and obstacles.World journal of stem cells · 2021
    Review
  20. Article

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Conor M RamsdenThe London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
Michael B Powner
Amanda-Jayne F Carr
Matthew J K Smart
Lyndon da Cruz
Peter J Coffey
University College London · GBMoorfields Eye Hospital NHS Foundation Trust · GBUniversity of California, Santa Barbara · US

Funding

Medical Research Council G0300288Medical Research Council G1000730
6 · The paper itself

Abstract

Stem cell therapy for retinal disease is under way, and several clinical trials are currently recruiting. These trials use human embryonic, foetal and umbilical cord tissue-derived stem cells and bone marrow-derived stem cells to treat visual disorders such as age-related macular degeneration, Stargardt's disease and retinitis pigmentosa. Over a decade of analysing the developmental cues involved in retinal generation and stem cell biology, coupled with extensive surgical research, have yielded differing cellular approaches to tackle these retinopathies. Here, we review these various stem cell-based approaches for treating retinal diseases and discuss future directions and challenges for the field.

Indexed as

RegenerationAnimalsBone MarrowClinical Trials as TopicEmbryonic Stem CellsHumansInduced Pluripotent Stem CellsMacular DegenerationPhotoreceptor Cells, VertebrateRatsRetinaRetinal Pigment EpitheliumRetinitis PigmentosaStem Cell TransplantationA ge-related macular degenerationClinical trialsRetinitis pigmentosaStargardt's diseaseStem cells

Identifiers

PMID23715550
PMCPMC3666384
OpenAlexW2008927161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.