ArticleNature communications2013
Involvement of the Wnt/β-catenin pathway in neurectoderm architecture in Platynereis dumerilii.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 86 citations in OpenAlex.
- Multifaceted conserved functions of Notch during post-embryonic neurogenesis in the annelid Platynereis.EMBO reports · 2026Article
- The Rich Evolutionary History of the Reactive Oxygen Species Metabolic Arsenal Shapes Its Mechanistic Plasticity at the Onset of Metazoan Regeneration.Molecular biology and evolution · 2025Article
- Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model.Nature communications · 2024Article
- Transcriptomic landscape of posterior regeneration in the annelid Platynereis dumerilii.BMC genomics · 2023Article
- Studying Annelida Regeneration Using Platynereis dumerilii.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Neural regulation of body polarities in nereid worm regeneration.FASEB bioAdvances · 2022Article
- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
- Article
- DNA methylation atlas and machinery in the developing and regenerating annelid Platynereis dumerilii.BMC biology · 2021Article
- Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects.Cell death & disease · 2021Article
- The development of early pioneer neurons in the annelid Malacoceros fuliginosus.BMC evolutionary biology · 2020Article
- Investigating cellular and molecular mechanisms of neurogenesis in Capitella teleta sheds light on the ancestor of Annelida.BMC evolutionary biology · 2020Article
- Article
- Differentiation of circulating neural progenitor cells in vitro on fibrin-based composite -matrix involves Wnt- β-catenin-like signaling.Journal of cell communication and signaling · 2019Article
- Article
- A novel microRNA located in theThe Journal of biological chemistry · 2017Article
- The Notch pathway in the annelid Platynereis: insights into chaetogenesis and neurogenesis processes.Open biology · 2017Article
- Neurotrophin, p75, and Trk Signaling Module in the Developing Nervous System of the Marine Annelid Platynereis dumerilii.BioMed research international · 2016Article
- The evolution of early neurogenesis.Developmental cell · 2015Review
- Dissecting the role of Wnt signaling and its interactions with FGF signaling during midbrain neurogenesis.Neurogenesis (Austin, Tex.) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signalling pathways are essential for the correct development of the central nervous system (CNS) in bilaterian animals. Here we show that in the CNS of the annelid Platynereis dumerilii, neural progenitor cells (NPCs) are located close to the ventral midline and express axin, a negative regulator of the Wnt/β-catenin pathway. Using pharmacological inhibitors, we observe that Wnt/β-catenin is required for the transition between proliferating NPCs and differentiating neurons. We also show that the Rho-associated kinase (Rok) is necessary for neurectoderm morphogenesis and ventral midline formation, and indirectly affects the distribution of the NPCs and the development of axonal scaffolds. Moreover, seven genes belonging to the planar cell polarity (PCP) pathway are expressed in the developing Platynereis neurectoderm, suggesting an involvement in its morphogenesis. When compared with previous studies in vertebrates, our data suggest that the involvement of the Wnt/β-catenin pathway in the control of neural cell proliferation/differentiation is ancestral to bilaterians.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.