Trial reportBrain : a journal of neurology2013
The right hemisphere supports but does not replace left hemisphere auditory function in patients with persisting aphasia.
Trial report in Brain : a journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Echoes of the spoken past: how auditory cortex hears context during speech perception.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Pooled it
- Training-Induced Neural Enhancement of Novel Song Learning in Chronic Aphasia: EEG Study.Annals of the New York Academy of Sciences · 2025Trial
- Auditory training changes temporal lobe connectivity in 'Wernicke's aphasia': a randomised trial.Journal of neurology, neurosurgery, and psychiatry · 2017Trial
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Human brain mapping · 2026Observational
- Effective neural connectivity deficits during speech auditory feedback processing in post-stroke aphasia: An fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Resting-state functional alterations in patients with brain arteriovenous malformations involving language areas.Human brain mapping · 2023Article
- Distinct neural signatures of schizotypy and psychopathy during visual word-nonword recognition.Human brain mapping · 2022Article
- Application of auditory mismatch negativity in tinnitus patients based on high-resolution electroencephalogram signals.Translational neuroscience · 2022Article
- Brain hemispheres with right temporal lobe damage swap dominance in early auditory processing of lexical tones.Frontiers in neuroscience · 2022Article
- Right-hemispheric language reorganization in patients with brain arteriovenous malformations: A functional magnetic resonance imaging study.Human brain mapping · 2021Article
- Organizing Variables Affecting fMRI Estimates of Language Dominance in Patients with Brain Tumors.Brain sciences · 2021Review
- Reappearance of Command-Following Is Associated With the Recovery of Language and Internal-Awareness Networks: A Longitudinal Multiple-Case Report.Frontiers in systems neuroscience · 2019Article
- Clinical subcategorization of minimally conscious state according to resting functional connectivity.Human brain mapping · 2018Article
- Brain, Behavior, and Cognitive Interplay in Disorders of Consciousness: A Multiple Case Study.Frontiers in neurology · 2018Article
- Functional activation independently contributes to naming ability and relates to lesion site in post-stroke aphasia.Human brain mapping · 2017Article
- Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia.Neural plasticity · 2017Article
- The "Hub Disruption Index," a Reliable Index Sensitive to the Brain Networks Reorganization. A Study of the Contralesional Hemisphere in Stroke.Frontiers in computational neuroscience · 2016Article
- Measuring vascular reactivity with breath-holds after stroke: a method to aid interpretation of group-level BOLD signal changes in longitudinal fMRI studies.Human brain mapping · 2015Article
- Ultra-rapid access to words in chronic aphasia: the effects of intensive language action therapy (ILAT).Brain topography · 2015Article
- Changes in task-based effective connectivity in language networks following rehabilitation in post-stroke patients with aphasia.Frontiers in human neuroscience · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
In this study, we used magnetoencephalography and a mismatch paradigm to investigate speech processing in stroke patients with auditory comprehension deficits and age-matched control subjects. We probed connectivity within and between the two temporal lobes in response to phonemic (different word) and acoustic (same word) oddballs using dynamic causal modelling. We found stronger modulation of self-connections as a function of phonemic differences for control subjects versus aphasics in left primary auditory cortex and bilateral superior temporal gyrus. The patients showed stronger modulation of connections from right primary auditory cortex to right superior temporal gyrus (feed-forward) and from left primary auditory cortex to right primary auditory cortex (interhemispheric). This differential connectivity can be explained on the basis of a predictive coding theory which suggests increased prediction error and decreased sensitivity to phonemic boundaries in the aphasics' speech network in both hemispheres. Within the aphasics, we also found behavioural correlates with connection strengths: a negative correlation between phonemic perception and an inter-hemispheric connection (left superior temporal gyrus to right superior temporal gyrus), and positive correlation between semantic performance and a feedback connection (right superior temporal gyrus to right primary auditory cortex). Our results suggest that aphasics with impaired speech comprehension have less veridical speech representations in both temporal lobes, and rely more on the right hemisphere auditory regions, particularly right superior temporal gyrus, for processing speech. Despite this presumed compensatory shift in network connectivity, the patients remain significantly impaired.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.