ArticleBrain : a journal of neurology2013
Increased gyrification, but comparable surface area in adolescents with autism spectrum disorders.
Article in Brain : a journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
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Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2021Pooled it
- Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.Translational psychiatry · 2021Pooled it
- Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study.Biological psychiatry global open science · 2026Article
- Neurobiological and Behavioral Heterogeneity in Adolescents with Autism Spectrum Disorder.Brain sciences · 2025Review
- Article
- Eigenvector Centrality Characterization on fMRI Data: Gender and Node Differences in Normal and ASD Subjects : Author name.Journal of autism and developmental disorders · 2024Article
- Morphometric network-based abnormalities correlate with psychiatric comorbidities and gene expression in PCDH19-related developmental and epileptic encephalopathy.Translational psychiatry · 2024Article
- Cortical signature of depressive symptoms in frontotemporal dementia: A surface-based analysis.Annals of clinical and translational neurology · 2023Article
- Cortical and subcortical morphological alteration in Angelman syndrome.Journal of neurodevelopmental disorders · 2023Article
- Structural brain abnormalities and their association with language impairment in school-aged children with Autism Spectrum Disorder.Scientific reports · 2023Article
- Exploring the heterogeneous morphometric data in essential tremor with probabilistic modelling.NeuroImage. Clinical · 2023Article
- Induction of cerebellar cortical neurogenesis immediately following valproic acid exposure in ferret kits.Frontiers in neuroscience · 2023Article
- The longitudinal bidirectional relationship between autistic traits and brain morphology from childhood to adolescence: a population-based cohort study.Molecular autism · 2022Article
- Cortical Gyrification Morphology in ASD and ADHD: Implication for Further Similarities or Disorder-Specific Features?Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Neurogenesis of Subventricular Zone Progenitors in the Premature Cortex of Ferrets Facilitated by Neonatal Valproic Acid Exposure.International journal of molecular sciences · 2022Article
- Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain.Communications medicine · 2022Article
- Age differences and brain maturation provide insight into heterogeneous results in autism spectrum disorder.Frontiers in human neuroscience · 2022Review
- Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms.Frontiers in psychiatry · 2022Article
- Cortical Morphology in Autism: Findings from a Cortical Shape-Adaptive Approach to Local Gyrification Indexing.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
18 more citing papers are in PubMed but not listed here.
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6 authors at 2 institutions in 2 countries.
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Abstract
Autism spectrum disorders are associated with atypically excessive early brain growth. Recent studies suggest that later cortical development, specifically cortical thickness, during adolescence and young adulthood is also aberrant. Nevertheless, previous studies of other surface-based metrics (e.g. surface area and gyrification) at high-resolution in autism spectrum disorders are limited. Forty-one males with autism spectrum disorders and 39 typically developing males matched on age (mean ≈ 17; range = 12-24 years) and IQ (mean ≈ 113; range = 85-143) provided high-resolution 3 T anatomical magnetic resonance imaging scans. The FreeSurfer image analysis suite quantified vertex-level surface area and gyrification. There were gyrification increases in the autism spectrum disorders group (relative to typically developing subjects) localized to bilateral posterior cortices (cluster corrected P < 0.01). Furthermore, the association between vocabulary knowledge and gyrification in left inferior parietal cortex (typically developing group: positive correlation; autism spectrum disorders group: no association) differed between groups. Finally, there were no group differences in surface area, and there was no interaction between age and group for either surface area or gyrification (both groups showed decreasing gyrification with increasing age). The present study complements and extends previous work by providing the first evidence of increased gyrification (though no differences in surface area) at high resolution among adolescents and young adults with autism spectrum disorders and by showing a dissociation in the relationship between vocabulary and gyrification in autism spectrum disorders versus typically developing subjects. In contrast with previous findings of age-related cortical thinning in this same autism spectrum disorders sample, here we find that increases in gyrification are maintained across adolescence and young adulthood, implicating developmentally dissociable cortical atypicalities in autism spectrum disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.