ArticleHeredity2013
Genetic mapping of variation in dauer larvae development in growing populations of Caenorhabditis elegans.
Article in Heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Opposing directions of stage-specific body shape change in a close relative of C. elegans.BMC zoology · 2022Article
- Review
- From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Trends in genetics : TIG · 2021Review
- Natural variation in fecundity is correlated with species-wide levels of divergence in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2021Article
- Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans.PLoS genetics · 2020Article
- WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans.Database : the journal of biological databases and curation · 2020Article
- Tightly linked antagonistic-effect loci underlie polygenic phenotypic variation inEvolution letters · 2019Article
- Selection and gene flow shape niche-associated variation in pheromone response.Nature ecology & evolution · 2019Article
- A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits.BMC biology · 2019Article
- Use of a Sibling Subtraction Method for Identifying Causal Mutations inG3 (Bethesda, Md.) · 2018Article
- Genetic Dissection of Morphometric Traits Reveals That Phytochrome B Affects Nucleus Size and Heterochromatin Organization inG3 (Bethesda, Md.) · 2017Article
- The Natural Biotic Environment ofGenetics · 2017Review
- Farming and public goods production inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Inverse correlation between longevity and developmental rate among wild C. elegans strains.Aging · 2016Article
- Natural Genetic Variation Differentially Affects the Proteome and Transcriptome in Caenorhabditis elegans.Molecular & cellular proteomics : MCP · 2016Article
- Genotype-dependent lifespan effects in peptone deprived Caenorhabditis elegans.Scientific reports · 2015Article
- Ten years of life in compost: temporal and spatial variation of North German Caenorhabditis elegans populations.Ecology and evolution · 2015Article
- Travelling at a slug's pace: possible invertebrate vectors of Caenorhabditis nematodes.BMC ecology · 2015Article
- The laboratory domestication of Caenorhabditis elegans.Trends in genetics : TIG · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the nematode Caenorhabditis elegans, the appropriate induction of dauer larvae development within growing populations is likely to be a primary determinant of genotypic fitness. The underlying genetic architecture of natural genetic variation in dauer formation has, however, not been thoroughly investigated. Here, we report extensive natural genetic variation in dauer larvae development within growing populations across multiple wild isolates. Moreover, bin mapping of introgression lines (ILs) derived from the genetically divergent isolates N2 and CB4856 reveals 10 quantitative trait loci (QTLs) affecting dauer formation. Comparison of individual ILs to N2 identifies an additional eight QTLs, and sequential IL analysis reveals six more QTLs. Our results also show that a behavioural, laboratory-derived, mutation controlled by the neuropeptide Y receptor homolog npr-1 can affect dauer larvae development in growing populations. These findings illustrate the complex genetic architecture of variation in dauer larvae formation in C. elegans and may help to understand how the control of variation in dauer larvae development has evolved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.