ArticleEuropean journal of human genetics : EJHG2014
A panel of ancestry informative markers to estimate and correct potential effects of population stratification in Han Chinese.
Article in European journal of human genetics : EJHG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Efficient amplicon panels for evaluating hybridization and genetic structure in the Schistosoma haematobium species group.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Bioinformatic insights into five Chinese population substructures inferred from the East Asian-specific AISNP panel.BMC genomics · 2025Article
- Whole mitochondrial genome analysis in highland Tibetans: further matrilineal genetic structure exploration.Frontiers in genetics · 2023Article
- Combined Low-/High-Density Modern and Ancient Genome-Wide Data Document Genomic Admixture History of High-Altitude East Asians.Frontiers in genetics · 2021Article
- MicroRNA Variants and HLA-miRNA Interactions are Novel Rheumatoid Arthritis Susceptibility Factors.Frontiers in genetics · 2021Article
- Next generation sequencing of a set of ancestry-informative SNPs: ancestry assignment of three continental populations and estimating ancestry composition for Mongolians.Molecular genetics and genomics : MGG · 2020Article
- PGG.Han: the Han Chinese genome database and analysis platform.Nucleic acids research · 2020Article
- Ancestry informative markers (AIMs) for Korean and other East Asian and South East Asian populations.International journal of legal medicine · 2019Article
- Identifying novel microhaplotypes for ancestry inference.International journal of legal medicine · 2019Article
- Targeted resequencing of 358 candidate genes for autism spectrum disorder in a Chinese cohort reveals diagnostic potential and genotype-phenotype correlations.Human mutation · 2019Article
- A set of novel SNP loci for differentiating continental populations and three Chinese populations.PeerJ · 2019Article
- Selection of Optimal Ancestry Informative Markers for Classification and Ancestry Proportion Estimation in Pigs.Frontiers in genetics · 2019Article
- Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations.Hereditas · 2018Article
- Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine.Scientific reports · 2017Article
- Relationship between Modulator Recognition Factor 2/AT-rich Interaction Domain 5B Gene Variations and Type 2 Diabetes Mellitus or Lipid Metabolism in a Northern Chinese Population.Chinese medical journal · 2017Article
- Multi-InDel Analysis for Ancestry Inference of Sub-Populations in China.Scientific reports · 2016Article
- Genetic structure and differentiation analysis of a Eurasian Uyghur population by use of 27 continental ancestry-informative SNPs.International journal of legal medicine · 2016Article
- Selection of highly informative SNP markers for population affiliation of major US populations.International journal of legal medicine · 2016Article
- A single-tube 27-plex SNP assay for estimating individual ancestry and admixture from three continents.International journal of legal medicine · 2016Article
- Genetic Variation of 25 Y-Chromosomal and 15 Autosomal STR Loci in the Han Chinese Population of Liaoning Province, Northeast China.PloS one · 2016Article
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9 authors.
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Abstract
Population stratification acts as a confounding factor in genetic association studies and may lead to false-positive or false-negative results. Previous studies have analyzed the genetic substructures in Han Chinese population, the largest ethnic group in the world comprising ∼20% of the global human population. In this study, we examined 5540 Han Chinese individuals with about 1 million single-nucleotide polymorphisms (SNPs) and screened a panel of ancestry informative markers (AIMs) to facilitate the discerning and controlling of population structure in future association studies on Han Chinese. Based on genome-wide data, we first confirmed our previous observation of the north-south differentiation in Han Chinese population. Second, we developed a panel of 150 validated SNP AIMs to determine the northern or southern origin of each Han Chinese individual. We further evaluated the performance of our AIMs panel in association studies in simulation analysis. Our results showed that this AIMs panel had sufficient power to discern and control population stratification in Han Chinese, which could significantly reduce false-positive rates in both genome-wide association studies (GWAS) and candidate gene association studies (CGAS). We suggest this AIMs panel be genotyped and used to control and correct population stratification in the study design or data analysis of future association studies, especially in CGAS which is the most popular approach to validate previous reports on genetic associations of diseases in post-GWAS era.
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