ArticleThe European journal of neuroscience2013
Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons.
Article in The European journal of neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 83 citations in OpenAlex.
- Prefrontal hypoactivity correlates with immediate extinction deficit following Pavlovian fear conditioning with a chasing threat.Psychopharmacology · 2025Article
- Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Expanding the canon: An inclusive neurobiology of thalamic and subthalamic fear circuits.Neuropharmacology · 2023Review
- Habit Formation and the Effect of Repeated Stress Exposures on Cognitive Flexibility Learning in Horses.Animals : an open access journal from MDPI · 2022Article
- Unrelenting Fear Under Stress: Neural Circuits and Mechanisms for the Immediate Extinction Deficit.Frontiers in systems neuroscience · 2022Review
- Environmental certainty influences the neural systems regulating responses to threat and stress.Neuroscience and biobehavioral reviews · 2021Review
- Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?International journal of molecular sciences · 2021Review
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- Prior stress followed by a novel stress challenge results in sex-specific deficits in behavioral flexibility and changes in gene expression in rat medial prefrontal cortex.Hormones and behavior · 2020Article
- Retrieval-Extinction and Relapse Prevention: Rewriting Maladaptive Drug Memories?Frontiers in behavioral neuroscience · 2020Review
- Effects of stress on the structure and function of the medial prefrontal cortex: Insights from animal models.International review of neurobiology · 2020Review
- Chronic Stress Causes Projection-Specific Adaptation of Amygdala Neurons via Small-Conductance Calcium-Activated Potassium Channel Downregulation.Biological psychiatry · 2019Article
- Mild blast-related TBI in a mouse model alters amygdalar neurostructure and circuitry.Experimental neurology · 2019Article
- Maturational Changes in Prefrontal and Amygdala Circuits in Adolescence: Implications for Understanding Fear Inhibition during a Vulnerable Period of Development.Brain sciences · 2019Review
- Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner.Biological psychiatry · 2019Article
- Chronic stress produces enduring sex- and region-specific alterations in novel stress-induced c-Fos expression.Neurobiology of stress · 2019Article
- Interventions after acute stress prevent its delayed effects on the amygdala.Neurobiology of stress · 2019Article
- Timing is everything: differential effects of chronic stress on fear extinction.Psychopharmacology · 2019Article
- Fear not: recent advances in understanding the neural basis of fear memories and implications for treatment development.F1000Research · 2019Review
- Rodent models of impaired fear extinction.Psychopharmacology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Stress-sensitive psychopathologies such as post-traumatic stress disorder are characterized by deficits in fear extinction and dysfunction of corticolimbic circuits mediating extinction. Chronic stress facilitates fear conditioning, impairs extinction, and produces dendritic proliferation in the basolateral amygdala (BLA), a critical site of plasticity for extinction. Acute stress impairs extinction, alters plasticity in the medial prefrontal cortex-to-BLA circuit, and causes dendritic retraction in the medial prefrontal cortex. Here, we examined extinction learning and basolateral amygdala pyramidal neuron morphology in adult male rats following a single elevated platform stress. Acute stress impaired extinction acquisition and memory, and produced dendritic retraction and increased mushroom spine density in basolateral amygdala neurons in the right hemisphere. Unexpectedly, irrespective of stress, rats that underwent fear and extinction testing showed basolateral amygdala dendritic retraction and altered spine density relative to non-conditioned rats, particularly in the left hemisphere. Thus, extinction deficits produced by acute stress are associated with increased spine density and dendritic retraction in basolateral amygdala pyramidal neurons. Furthermore, the finding that conditioning and extinction as such was sufficient to alter basolateral amygdala morphology and spine density illustrates the sensitivity of basolateral amygdala morphology to behavioral manipulation. These findings may have implications for elucidating the role of the amygdala in the pathophysiology of stress-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.