Evidence map›Paper›PMID 23714311›Full record

ReviewHematology/oncology clinics of North America2013

Diagnosis and management of heparin-induced thrombocytopenia.

Grace M Lee, Gowthami M Arepally

Open access · greenAbstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Grace M LeeDivision of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Gowthami M Arepally
Duke Medical Center · US

Funding

Protein CoreP01HL110860 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI CINES, DOUGLAS BROCK · 2012 to 2016
$11.4M
TRANSFUSION MEDICINE AND RELATED AREAST32HL007057 · NHLBI · DUKE UNIVERSITY · PI Gowthami M Arepally · 1985 to 2026
$10.6M
Immune Dysregulation in HITR01HL081395 · NHLBI · DUKE UNIVERSITY · PI AREPALLY, GOWTHAMI M · 2006 to 2010
$2.0M
Clinical Significance of protamine/heparin antibodies after CPBR21HL109825 · NHLBI · DUKE UNIVERSITY · PI AREPALLY, GOWTHAMI M · 2011 to 2012
$432k
Modeling the spectrum of HIT pathobiologyR03AI101992 · NIAID · DUKE UNIVERSITY · PI AREPALLY, GOWTHAMI M · 2012 to 2013
$157k
NHLBI NIH HHS 2T32HL007057-36NHLBI NIH HHS HL109825NHLBI NIH HHS HL110860NHLBI NIH HHS P01 HL110860NHLBI NIH HHS R01 HL081395NHLBI NIH HHS R21 HL109825NHLBI NIH HHS T32 HL007057NIAID NIH HHS AI101992NIAID NIH HHS R03 AI101992
6 · The paper itself

Abstract

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies to platelet factor 4/heparin (PF4/H) complexes. It presents with declining platelet counts 5 to 14 days after heparin administration and results in a predisposition to arterial and venous thrombosis. Establishing the diagnosis of HIT can be extremely challenging. It is essential to conduct a thorough clinical evaluation in addition to laboratory testing to confirm the presence of PF4/H antibodies. Multiple clinical algorithms have been developed to aid the clinician in predicting the likelihood of HIT. Once HIT is recognized, an alternative anticoagulant should be initiated to prevent further complications.

Indexed as

AlgorithmsHeparinHumansThrombocytopeniaHeparin

Identifiers

PMID23714311
PMCPMC3668315
OpenAlexW2009683651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.