ArticleBiomacromolecules2013
Peptide fibrils with altered stability, activity, and cell selectivity.
Article in Biomacromolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship Between Self-assembly and Cytolytic Activity.Angewandte Chemie (International ed. in English) · 2025Article
- Self-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates forGels (Basel, Switzerland) · 2025Article
- Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection.Journal of nanobiotechnology · 2024Article
- Structure-activity relationships of antibacterial peptides.Microbial biotechnology · 2023Review
- Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp.Pharmaceutics · 2021Article
- Key Physicochemical Determinants in the Antimicrobial Peptide RiLK1 Promote Amphipathic Structures.International journal of molecular sciences · 2021Article
- Nanostructured Antimicrobial Peptides: Crucial Steps of Overcoming the Bottleneck for Clinics.Frontiers in microbiology · 2021Review
- Lipid membrane interactions of self-assembling antimicrobial nanofibers: effect of PEGylation.RSC advances · 2020Article
- Peptide oligomers from ultra-short peptides using sortase.Biochemistry and biophysics reports · 2017Article
- Effect of position-specific single-point mutations and biophysical characterization of amyloidogenic peptide fragments identified from lattice corneal dystrophy patients.The Biochemical journal · 2017Article
- The potential roles of cell surface pHs in bioactive peptide activation.Chemical biology & drug design · 2015Article
- Bacteria responsive antibacterial surfaces for indwelling device infections.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Peptides have some unique and superior features compared to proteins. However, the use of peptides as therapeutics is hampered by their low stability and cell selectivity. In this study, a new lytic peptide (CL-1, FLGALFRALSRLL) was constructed. Under the physiological condition, peptide CL-1 self-assembled into dynamically stable aggregates with fibrils-like structures. Aggregated CL-1 demonstrated dramatically altered activity and stability in comparison with single molecule CL-1 and other lytic peptides: when incubated with cocultured bacteria and tissue cells, CL-1 aggregates killed bacteria selectively but spared cocultured human cells; CL-1 aggregates were kept intact in human serum for more than five hours. Peptide-cell interaction studies performed on lipid monolayers and live human tissue cells revealed that in comparison with monomeric CL-1, aggregated CL-1 had decreased cell affinity and membrane insertion capability on tissue cells. A dynamic process involving aggregate dissociation and rearrangement seemed to be an essential step for membrane bound CL-1 aggregates to realize its cytotoxicity to tissue cells. Our study suggests that peptide aggregation could be as important as the charge and secondary structure of a peptide in affecting peptide-cell interactions. Controlling peptide self-assembly represents a new way to increase the stability and cell selectivity of bioactive peptides for wide biomedical applications.
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Registered trials
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