ArticleLangmuir : the ACS journal of surfaces and colloids2013
Role of squalene in the organization of monolayers derived from lipid extracts of Halobacterium salinarum.
Article in Langmuir : the ACS journal of surfaces and colloids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Intercalant Aggregation Promotes Nanoscopic Depletion in Droplet Interface Bilayers.The journal of physical chemistry. B · 2025Article
- Functional diversity of nanohaloarchaea within xylan-degrading consortia.Frontiers in microbiology · 2023Article
- The squalene route to C30 carotenoid biosynthesis and the origins of carotenoid biosynthetic pathways.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genomic analysis of heavy metal-resistant Halobacterium salinarum isolated from Sfax solar saltern sediments.Extremophiles : life under extreme conditions · 2022Article
- Vesicular and Planar Membranes of Archaea Lipids: Unusual Physical Properties and Biomedical Applications.International journal of molecular sciences · 2022Review
- Prediction and Inferred Evolution of Acid Tolerance Genes in the Biotechnologically ImportantFrontiers in microbiology · 2022Article
- Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics.International journal of molecular sciences · 2021Article
- Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy.Frontiers in molecular biosciences · 2021Review
- Apolar Polyisoprenoids Located in the Midplane of the Bilayer Regulate the Response of an Archaeal-Like Membrane to High Temperature and Pressure.Frontiers in chemistry · 2020Article
- Entropic effects enable life at extreme temperatures.Science advances · 2019Article
- Squalene Found in Alpine Grassland Soils under a Harsh Environment in the Tibetan Plateau, China.Biomolecules · 2018Article
- Evaporation-induced monolayer compression improves droplet interface bilayer formation using unsaturated lipids.Biomicrofluidics · 2018Article
- Adaptations of archaeal and bacterial membranes to variations in temperature, pH and pressure.Extremophiles : life under extreme conditions · 2017Review
- Sebum/Meibum Surface Film Interactions and Phase Transitional Differences.Investigative ophthalmology & visual science · 2016Article
- Surface Properties of Squalene/Meibum Films and NMR Confirmation of Squalene in Tears.International journal of molecular sciences · 2015Article
- Exploring the existence of lipid rafts in bacteria.Microbiology and molecular biology reviews : MMBR · 2015Article
- Membrane homeoviscous adaptation in the piezo-hyperthermophilic archaeon Thermococcus barophilus.Frontiers in microbiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have studied interfacial compressibility and lateral organization in monolayer configurations of total (squalene containing) and polar (squalene-devoid) lipid extracts of Halobacterium salinarum NRC-1, an extremely halophilic archaeon. Pressure-area isotherms derived from Langmuir experiments reveal that packing characteristics and elastic compressibility are strongly influenced by the presence of squalene in the total lipid extract. In conjunction with control experiments using mixtures of DPhPC and squalene, our results establish that the presence of squalene significantly extends elastic area compressibility of total lipid extracts, suggesting it has a role in facilitating tighter packing of archaeal lipid mixtures. Moreover, we find that squalene also influences spatial organization in archaeal membranes. Epifluorescence and atomic force microscopy characterization of Langmuir monolayers transferred onto solid hydrophilic substrates reveal an unusual domain morphology. Individual domains of microscopic dimensions (as well as their extended networks) exhibiting a peculiar bowl-like topography are evident in atomic force microscopy images. The tall rims outlining individual domains indicate that squalene accumulates at the domain periphery in a manner similar to the accumulation of cholesterol at domain boundaries in their mixtures with phospholipids. Taken together, the results presented here support the notion that squalene plays a role in modulating molecular packing and lateral organization (i.e., domain formation) in the membranes of archaea analogous to that of cholesterol in eukaryotic membranes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.