ArticleRehabilitation psychology2013
The co-occurrence of pain and depression in adults with multiple sclerosis.
Article in Rehabilitation psychology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mindfulness-based Cognitive Therapy and Cognitive Behavioral Therapy for Chronic Pain in Multiple Sclerosis
Efficacy of a Telehealth Pain Self-Management Intervention in Employed Adults With Physical Disability: A Randomized Controlled Trial
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Translation, Cross-Cultural Adaptation, and Psychometric Properties of the Arabic Version of the MOS Pain Effect Scale in Individuals with Multiple Sclerosis.Healthcare (Basel, Switzerland) · 2026Article
- Efficacy of Transcranial Direct Current Stimulation (tDCS) on Neuropsychiatric Symptoms in Multiple Sclerosis (MS)-A Review and Insight into Possible Mechanisms of Action.Journal of clinical medicine · 2024Review
- Impact of Multiple Sclerosis and Its Association with Depression: An Analytical Case-Control Investigation.Healthcare (Basel, Switzerland) · 2022Article
- Coupling cognitive and brainstem dysfunction in multiple sclerosis-related chronic neuropathic limb pain.Brain communications · 2022Article
- Prioritizing progressive MS rehabilitation research: A call from the International Progressive MS Alliance.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Neuropathic Pain in Multiple Sclerosis and Its Animal Models: Focus on Mechanisms, Knowledge Gaps and Future Directions.Frontiers in neurology · 2021Review
- Preclinical Considerations about Affective Disorders and Pain: A Broadly Intertwined, yet Often Under-Explored, Relationship Having Major Clinical Implications.Medicina (Kaunas, Lithuania) · 2020Review
- Anxiety and depression in Multiple Sclerosis (MS): Antecedents, consequences, and differential impact on well-being and quality of life.Multiple sclerosis and related disorders · 2020Article
- Positive factors, pain, and function in adults with multiple sclerosis.Rehabilitation psychology · 2018Article
- Review
- Pain, Fatigue, and Cognitive Symptoms Are Temporally Associated Within but Not Across Days in Multiple Sclerosis.Archives of physical medicine and rehabilitation · 2017Article
- Pain in People with Multiple Sclerosis: Associations with Modifiable Lifestyle Factors, Fatigue, Depression, Anxiety, and Mental Health Quality of Life.Frontiers in neurology · 2017Article
- Relative Importance of Baseline Pain, Fatigue, Sleep, and Physical Activity: Predicting Change in Depression in Adults With Multiple Sclerosis.Archives of physical medicine and rehabilitation · 2016Observational
- The interrelations between spiritual well-being, pain interference and depressive symptoms in patients with multiple sclerosis.Journal of behavioral medicine · 2016Article
- Utilization and patients' perceptions of the effectiveness of pain treatments in multiple sclerosis: A cross-sectional survey.Disability and health journal · 2015Article
- A Fresh Look at the Potential Mechanisms of Progressive Muscle Relaxation Therapy on Depression in Female Patients With Multiple Sclerosis.Iranian journal of psychiatry and behavioral sciences · 2015Article
- Pain affects depression through anxiety, fatigue, and sleep in multiple sclerosis.Rehabilitation psychology · 2015Article
- The link between multiple sclerosis and depression.Nature reviews. Neurology · 2014Review
- Quality of life outcomes following surgery for patients with coexistent cervical stenosis and multiple sclerosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
PURPOSE/
objectiveTo define the rates of pain, depression, and their co-occurrence in persons with multiple sclerosis (MS). RESEARCH METHOD/
designParticipants were 161 persons with MS who previously participated in research and indicated a willingness to be contacted for future studies. Data were collected via postal survey and included the Patient Health Questionnaire-9 for depressive symptoms and a numerical rating scale (0-10) for pain. Descriptive statistics, chi-square analyses, and odds ratios were calculated to describe the prevalence, difference, and likelihood of depression, pain, and their comorbidity.
resultsSome level of pain was experienced by 73% of the sample, with 40% of the entire sample reporting moderate or worse pain severity. Clinically significant levels of depressive symptoms were reported by 22% of the sample, and 8% reported sufficient symptoms to meet major depressive episode diagnostic criteria. Of persons meeting depression criteria, 86-100% reported experiencing any pain; 67-77% of persons meeting depression criteria reported experiencing pain of at least moderate severity. Of persons experiencing any pain, 11-34% met depression criteria; 15-37% of persons experiencing pain of at least moderate severity met depression criteria. CONCLUSIONS/IMPLICATIONS: Pain and depression co-occur frequently in persons with MS. However, it is more common for individuals with depression to report pain than for individuals with pain to endorse symptoms of depression. Future studies should explore the implications of this co-occurrence, such as whether these individuals experience greater levels of disability, higher medical costs, or fewer benefits from treatment than persons with either condition alone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.