ArticleClinical and experimental pharmacology & physiology2013
Endothelin ET(B) receptors contribute to sex differences in blood pressure elevation in angiotensin II hypertensive rats on a high-salt diet.
Article in Clinical and experimental pharmacology & physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Adipocyte-specific ETPhysiological reports · 2025Article
- Maternal melatonin treatment rescues endocrine, inflammatory, and transcriptional deregulation in the adult rat female offspring from gestational chronodisruption.Frontiers in neuroscience · 2022Article
- Diabetes-related sex differences in the brain endothelin system following ischemia in vivo and in human brain endothelial cells in vitro.Canadian journal of physiology and pharmacology · 2020Article
- New Mechanism for the Sex Differences in Salt-Sensitive Hypertension: The Role of Macula Densa NOS1β-Mediated Tubuloglomerular Feedback.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Voluntary Wheel Running Attenuates Salt-Induced Vascular Stiffness Independent of Blood Pressure.American journal of hypertension · 2019Article
- Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan.American journal of physiology. Heart and circulatory physiology · 2018Review
- Lack of Suppression of Aldosterone Production Leads to Salt-Sensitive Hypertension in Female but Not Male Balb/C Mice.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Natriuretic response to renal medullary endothelin B receptor activation is impaired in Dahl-salt sensitive rats on a high-fat diet.Physiological research · 2018Article
- Sex-specific differences in hypertension and associated cardiovascular disease.Nature reviews. Nephrology · 2018Review
- Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.American journal of physiology. Renal physiology · 2017Article
- ETAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Loss of endothelin B receptor function impairs sodium excretion in a time- and sex-dependent manner.American journal of physiology. Renal physiology · 2016Article
- Role of the endothelin system in sexual dimorphism in cardiovascular and renal diseases.Life sciences · 2016Review
- Ovarian hormones modulate endothelin A and B receptor expression.Life sciences · 2016Article
- Novel relationships of markers of monocyte activation and endothelial dysfunction with pulmonary dysfunction in HIV-infected persons.AIDS (London, England) · 2016Observational
- Endothelin.Pharmacological reviews · 2016Review
- The Role of Endothelin System in Renal Structure and Function during the Postnatal Development of the Rat Kidney.PloS one · 2016Article
- Endothelin-1 and the kidney: new perspectives and recent findings.Current opinion in nephrology and hypertension · 2016Review
- Sex-Specific Effect of Endothelin in the Blood Pressure Response to Acute Angiotensin II in Growth-Restricted Rats.Hypertension (Dallas, Tex. : 1979) · 2015Article
- High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient rats.Physiological reports · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Female rats are more resistant to blood pressure increases induced by high salt (HS) intake or angiotensin (Ang) II infusion. Because endothelin ET(B) receptors on endothelial and epithelial cells mediate tonic vasodilation and sodium excretion, we hypothesized that ET(B) receptors limit the hypertensive response and renal injury induced by HS diet alone or with chronic AngII infusion (AngII/HS) in female compared with male rats. A 4 week HS diet (4% NaCl) did not significantly change blood pressure (measured by telemetry) in either male or female Sprague-Dawley rats. Administration of the ET(B) receptor antagonist A-192621 (1, 3 and 10 mg/kg per day in food) during HS feeding caused a dose-dependent increase in blood pressure in both sexes. In AngII/HS rats, males had a larger increase in blood pressure than females. The increase in blood pressure produced by ET(B) receptor blockade in male AngII/HS rats was not significant. However, A-192621 treatment resulted in a significant further increase in blood pressure in female AngII/HS rats. Male rats had consistently higher protein excretion rates before and during AngII/HS, but this was not significantly affected by ET(B) receptor blockade in either sex. In conclusion, ET(B) receptors play a significantly greater beneficial role in protecting female compared with male rats against AngII-induced hypertension and may contribute to the sex differences in AngII-induced hypertension.
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