SynthesisPediatrics2013
Systematic review of prenatal cocaine exposure and adolescent development.
Synthesis in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Prenatal drug exposure, behavioral problems, and drug experimentation among African-American urban adolescents.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2014Trial
- Heterogeneity in Callous-Unemotional Traits: Early Temperamental and Environmental Risk Factors in a High-Risk Sample.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Caregiving Environmental Risk and Aggression From Infancy to Adolescence in a High-Risk Sample: An Examination of Between-Family and Within-Family Effects.Aggressive behavior · 2025Article
- Accidental Detection of Cocaine in Urine in Pediatric Patients: Case Series and Literature Review.Children (Basel, Switzerland) · 2024Article
- Effectiveness of Psychotropic Medications in Children with Prenatal Alcohol and Drug Exposures: A Case Series and Model of Care.Child psychiatry and human development · 2024Article
- Prenatal cocaine exposure and self-reported behavioral adjustments from ages 12 to 21: environmental pathways.Psychological medicine · 2024Article
- Prenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans.Scientific reports · 2024Article
- Adverse childhood experiences and neurodevelopmental disorders among youth with and without prenatal substance exposure: A longitudinal matched register-based cohort study.Nordisk alkohol- & narkotikatidskrift : NAT · 2023Article
- Early emotional caregiving environment and associations with memory performance and hippocampal volume in adolescents with prenatal drug exposure.Frontiers in behavioral neuroscience · 2023Article
- Child Community Violence Exposure in an at-Risk Sample: Developmental Trajectories, Caregiving Risks, and the Role of Child Temperament.Psychology of violence · 2022Article
- Development of Bullying and Victimization: An Examination of Risk and Protective Factors in a High-Risk Sample.Journal of interpersonal violence · 2022Article
- Mapping the literature on parents with mental illness, across psychiatric sub-disciplines: a bibliometric review.BMC psychiatry · 2020Review
- Associations of Maternal Prenatal Drug Abuse With Measures of Newborn Brain Structure, Tissue Organization, and Metabolite Concentrations.JAMA pediatrics · 2020Article
- Prenatal substance exposure, adverse childhood experiences and diagnosed mental and behavioral disorders - A longitudinal register-based matched cohort study in Finland.SSM - population health · 2020Article
- Cohort profile: ADEF Helsinki - a longitudinal register-based study on exposure to alcohol and drugs during foetal life.Nordisk alkohol- & narkotikatidskrift : NAT · 2020Article
- Family Environment, Neurodevelopmental Risk, and the Environmental Influences on Child Health Outcomes (ECHO) Initiative: Looking Back and Moving Forward.Frontiers in psychiatry · 2020Review
- Proceedings of the 2018 annual meeting of the Fetal Alcohol Spectrum Disorders study group.Alcohol (Fayetteville, N.Y.) · 2019Article
- Opioid Use by Pregnant and Parenting Women: Let's Not Repeat the Mistakes of 25 Years Ago.The Milbank quarterly · 2019Article
- Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2019Article
- Prenatal cocaine exposure: Direct and indirect associations with 21-year-old offspring substance use and behavior problems.Drug and alcohol dependence · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND AND
objectivePrevious research found that prenatal cocaine exposure (PCE) may increase children's vulnerability to behavior and cognition problems. Maturational changes in brain and social development make adolescence an ideal time to reexamine associations. The objective was to conduct a systematic review of published studies examining associations between PCE and adolescent development (behavior, cognition/school outcomes, physiologic responses, and brain morphology/functioning).
methodsArticles were obtained from PubMed, PsycInfo, Web of Science, and CINAHL databases through July 2012 with search terms: prenatal drug, substance, or cocaine exposure; adolescence/adolescent; and in utero substance/drug exposure. Criteria for inclusion were nonexposed comparison group, human adolescents aged 11 to 19, peer-reviewed, English-language, and adolescent outcomes.
resultsTwenty-seven studies representing 9 cohorts met the criteria. Four outcome categories were identified: behavior, cognition/school performance, brain structure/function, and physiologic responses. Eleven examined behavior; 7 found small but significant differences favoring nonexposed adolescents, with small effect sizes. Eight examined cognition/school performance; 6 reported significantly lower scores on language and memory tasks among adolescents with PCE, with varying effect sizes varied. Eight examined brain structure/function and reported morphologic differences with few functional differences. Three examined physiologic responses with discordant findings. Most studies controlled for other prenatal exposures, caregiving environment, and violence exposure; few examined mechanisms.
conclusionsConsistent with findings among younger children, PCE increases the risk for small but significantly less favorable adolescent functioning. Although the clinical importance of differences is often unknown, the caregiving environment and violence exposure pose additional threats. Future research should investigate mechanisms linking PCE with adolescent functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.