ArticleThe Journal of physiology2013
Muscle metaboreflex and autonomic regulation of heart rate in humans.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Low-Load Blood Flow Restriction Training on Hemodynamic Responses and Vascular Function in Older Adults: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Metaboreflex activation delays heart rate recovery after aerobic exercise in never-treated hypertensive men.The Journal of physiology · 2016Trial
- Ischemic preconditioning reduces hemodynamic response during metaboreflex activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Autonomic control of cardiac rhythm at the onset of muscle metaboreflex activation following exercise in healthy young and old adults.Physiological reports · 2026Article
- Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026Review
- Exploring acute physiological adaptations to circuit strength training: the role of work-to-rest interval variations.Scientific reports · 2026Article
- Sex-based comparison of the blood pressure, haemodynamic and cardiac autonomic adaptations following isometric exercise training in sedentary adults: a randomised controlled trial.BMJ open sport & exercise medicine · 2025Article
- The influence of oral contraceptives on the exercise pressor reflex in the upper and lower body.Physiological reports · 2024Article
- Augmented sympathoexcitation slows postexercise heart rate recovery.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- The effects of type of recovery in resistance exercise on responses of platelet indices and hemodynamic variables.PloS one · 2023Article
- The exercise pressor reflex: An update.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Ischemic preconditioning of the muscle reduces the metaboreflex response of the knee extensors.European journal of applied physiology · 2022Article
- Article
- Vagal blockade suppresses the phase I heart rate response but not the phase I cardiac output response at exercise onset in humans.European journal of applied physiology · 2021Article
- A brief bout of exercise in hypoxia reduces ventricular filling rate and stroke volume response during muscle metaboreflex activation.European journal of applied physiology · 2020Article
- Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise.American journal of physiology. Heart and circulatory physiology · 2020Review
- Blood Pressure Increase in Hypertensive Individuals During Resistance Training Protocols With Equated Work to Rest Ratio.Frontiers in physiology · 2020Article
- Gender Differences in Hemodynamic Regulation and Cardiovascular Adaptations to Dynamic Exercise.Current cardiology reviews · 2020Review
- Effects of exercise in normobaric hypoxia on hemodynamics during muscle metaboreflex activation in normoxia.European journal of applied physiology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We elucidated the autonomic mechanisms whereby heart rate (HR) is regulated by the muscle metaboreflex. Eight male participants (22 ± 3 years) performed three exercise protocols: (1) enhanced metaboreflex activation with partial flow restriction (bi-lateral thigh cuff inflation) during leg cycling exercise, (2) isolated muscle metaboreflex activation (post-exercise ischaemia; PEI) following leg cycling exercise, (3) isometric handgrip followed by PEI. Trials were undertaken under control (no drug), β1-adrenergic blockade (metoprolol) and parasympathetic blockade (glycopyrrolate) conditions. HR increased with partial flow restriction during leg cycling in the control condition (11 ± 2 beats min(-1); P < 0.05). The magnitude of this increase in HR was similar with parasympathetic blockade (11 ± 2 beats min(-1)), but attenuated with β-adrenergic blockade (4 ± 1 beats min(-1); P < 0.05 vs. control and parasympathetic blockade). During PEI following leg cycling exercise, HR remained similarly elevated above rest under all conditions (11 ± 2, 13 ± 3 and 9 ± 4 beats min(-1), for control, β-adrenergic and parasympathetic blockade; P > 0.05 between conditions). During PEI following handgrip, HR was similarly elevated from rest under control and parasympathetic blockade (4 ± 1 vs. 4 ± 2 beats min(-1); P > 0.05 between conditions) conditions, but attenuated with β-adrenergic blockade (0.2 ± 1 beats min(-1); P > 0.05 vs. rest). Thus muscle metaboreflex activation-mediated increases in HR are principally attributable to increased cardiac sympathetic activity, and only following exercise with a large muscle mass (PEI following leg cycling) is there a contribution from the partial withdrawal of cardiac parasympathetic tone.
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Registered trials
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