ArticleThe Journal of physiology2013
The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Patterns of Abnormal Gastric Pacemaking After Sleeve Gastrectomy Defined by Laparoscopic High-Resolution Electrical Mapping.Obesity surgery · 2017Trial
- Gastric slow-wave morphology in health and disease.Digestive diseases and sciences · 2026Article
- Body surface gastric mapping facilitates the management of pediatric disorders of gut-brain interaction.Therapeutic advances in gastroenterology · 2025Review
- Local Myoelectric Sensing During Human Colonic Tissue Perfusion.Diagnostics (Basel, Switzerland) · 2024Article
- [A New Paradigm in Diagnosing Functional Gastroduodenal Disorders: High-Resolution Electrogastrography].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Review
- Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Principles and clinical methods of body surface gastric mapping: Technical review.Neurogastroenterology and motility · 2023Review
- Power-Controlled, Irrigated Radio-Frequency Ablation of Gastric Tissue: A Biophysical Analysis of Lesion Formation.Digestive diseases and sciences · 2023Article
- Tracking Gut Motility in Organ and Cultures.Methods in molecular biology (Clifton, N.J.) · 2023Article
- High-resolution in vivo monophasic gastric slow waves to quantify activation and recovery profiles.Neurogastroenterology and motility · 2022Article
- Relationship Between Intestinal Slow-waves, Spike-bursts, and Motility, as Defined Through High-resolution Electrical and Video Mapping.Journal of neurogastroenterology and motility · 2022Article
- Gastric dysfunction in patients with chronic nausea and vomiting syndromes defined by a noninvasive gastric mapping device.Science translational medicine · 2022Article
- In vivo experimental validation of detection of gastric slow waves using a flexible multichannel electrogastrography sensor linear array.Biomedical engineering online · 2022Article
- Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Intraoperative serosal extracellular mapping of the human distal colon: a feasibility study.Biomedical engineering online · 2021Article
- Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches.Frontiers in neuroscience · 2021Review
- The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach.Physiological reports · 2021Article
- Electrogastrography for psychophysiological research: Practical considerations, analysis pipeline, and normative data in a large sample.Psychophysiology · 2020Review
- Slow-wave coupling across a gastroduodenal anastomosis as a mechanism for postsurgical gastric dysfunction: evidence for a "gastrointestinal aberrant pathway".American journal of physiology. Gastrointestinal and liver physiology · 2019Article
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Abstract
Gastrointestinal extracellular recordings have been a core technique in motility research for a century. However, the bioelectrical basis of extracellular data has recently been challenged by claims that these techniques preferentially assay movement artifacts, cannot reproduce the underlying slow wave kinetics, and misrepresent the true slow wave frequency. These claims motivated this joint experimental-theoretical study, which aimed to define the sources and validity of extracellular potentials. In vivo extracellular recordings and video capture were performed in the porcine jejunum, before and after intra-arterial nifedipine administration. Gastric extracellular recordings were recorded simultaneously using conventional serosal contact and suction electrodes, and biphasic and monophasic extracellular potentials were simulated in a biophysical model. Contractions were abolished by nifedipine, but extracellular slow waves persisted, with unchanged amplitude, downstroke rate, velocity, and downstroke width (P>0.10 for all), at reduced frequency (24% lower; P=0.03). Simultaneous suction and conventional serosal extracellular recordings were identical in phase (frequency and activation-recovery interval), but varied in morphology (monophasic vs. biphasic; downstroke rate and amplitude: P<0.0001). Simulations demonstrated the field contribution of current flow to extracellular potential and quantified the effects of localised depolarisation due to suction pressure on extracellular potential morphology. In sum, these results demonstrate that gastrointestinal extracellular slow wave recordings cannot be explained by motion artifacts, and are of a bioelectrical origin that is highly consistent with the underlying biophysics of slow wave propagation. Motion suppression is shown to be unnecessary as a routine control in in vivo extracellular studies, supporting the validity of the extant gastrointestinal extracellular literature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.