ArticleExtremophiles : life under extreme conditions2013
The HOG signal transduction pathway in the halophilic fungus Wallemia ichthyophaga: identification and characterisation of MAP kinases WiHog1A and WiHog1B.
Article in Extremophiles : life under extreme conditions, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 30 citations in OpenAlex.
- Genome Sequencing and Comparative Transcriptomic Analysis of Rice Brown Spot PathogenJournal of fungi (Basel, Switzerland) · 2025Article
- Halophilic Fungi-Features and Potential Applications.Microorganisms · 2025Review
- Extreme environments offer an unprecedented opportunity to understand microbial eukaryotic ecology, evolution, and genome biology.Nature communications · 2023Review
- Metabolic Potential of Halophilic Filamentous Fungi-Current Perspective.International journal of molecular sciences · 2022Review
- Recent developments in the biology and biotechnological applications of halotolerant yeasts.World journal of microbiology & biotechnology · 2022Review
- Sensing and Responding to Hypersaline Conditions and the HOG Signal Transduction Pathway in Fungi Isolated from Hypersaline Environments:Journal of fungi (Basel, Switzerland) · 2021Review
- Regulation of biotic interactions and responses to abiotic stresses by MAP kinase pathways in plant pathogenic fungi.Stress biology · 2021Review
- Molecular cloning and sequence analysis of a mitogen-activated protein kinase gene in the Antarctic yeast Rhodotorula mucilaginosa AN5.Molecular biology reports · 2021Article
- Osmolyte Signatures for the Protection ofJournal of fungi (Basel, Switzerland) · 2021Article
- Genome-wide identification and expression profile analysis of the HOG gene family in Aspergillus oryzae.World journal of microbiology & biotechnology · 2018Article
- SakA and MpkC Stress MAPKs Show Opposite and Common Functions During Stress Responses and Development inFrontiers in microbiology · 2018Article
- Reconstruction of the High-Osmolarity Glycerol (HOG) Signaling Pathway from the Halophilic Fungus Wallemia ichthyophaga in Saccharomyces cerevisiae.Frontiers in microbiology · 2016Article
- Role of two Nomuraea rileyi transmembrane sensors Sho1p and Sln1p in adaptation to stress due to changing culture conditions during microsclerotia development.World journal of microbiology & biotechnology · 2015Article
- Identification of a novel HOG1 homologue from an industrial glycerol producer Candida glycerinogenes.Current microbiology · 2014Article
- Osmoadaptation strategy of the most halophilic fungus, Wallemia ichthyophaga, growing optimally at salinities above 15% NaCl.Applied and environmental microbiology · 2014Article
- Article
- Adaptation to high salt concentrations in halotolerant/halophilic fungi: a molecular perspective.Frontiers in microbiology · 2014Review
- Genome and transcriptome sequencing of the halophilic fungus Wallemia ichthyophaga: haloadaptations present and absent.BMC genomics · 2013Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The high-osmolarity glycerol (HOG) pathway is one of the several MAP kinase cascades in fungi. It is the main signal transduction system that is responsible for cellular stress responses, and has primarily been studied in the context of osmotic stress. In the present study, we provide the first insights into the HOG pathway of the obligatory halophilic basidiomycetous fungus Wallemia ichthyophaga, with the characterisation of its two Hog1-like kinases: WiHog1A and WiHog1B. These share high similarity to Hog1 kinase from Saccharomyces cerevisiae (ScHog1) at the level of amino-acid sequence. While WiHog1A could not optimally complement the function of ScHog1, WiHog1B was a fully functional Hog1-like kinase and could improve the halotolerance of the yeast, compared to the wild-type or the ScHog1-expressing hog1Δ strain. In W. ichthyophaga cells, Hog1 was constitutively phosphorylated under optimal osmotic conditions and dephosphorylated when the cells were challenged with hypo-osmolar or hyperosmolar stress. This pattern of phosphorylation kinetics is opposite to that of yeast. Transcriptional analysis of these two kinases in W. ichthyophaga shows that WiHOG1B is more responsive to changes in NaCl concentrations than WiHOG1A. Our identification and characterisation of these Hog1-like kinases from W. ichthyophaga confirm the existence of the HOG signalling pathway and its role in osmosensing in this halophilic fungus.
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