ArticleAdvanced materials (Deerfield Beach, Fla.)2013
Enzyme-directed assembly of a nanoparticle probe in tumor tissue.
Article in Advanced materials (Deerfield Beach, Fla.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 82 citations in OpenAlex.
- Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to Acute Myocardial Infarction.Biomacromolecules · 2023Article
- Tailoring the AIE Chromogen 2-(2-Hydroxyphenyl)benzothiazole for Use in Enzyme-Triggered Molecular Brachytherapy.Molecules (Basel, Switzerland) · 2022Article
- Supramolecular Nanomedicines ofFrontiers in chemistry · 2022Review
- Innovations in Disease State Responsive Soft Materials for Targeting Extracellular Stimuli Associated with Cancer, Cardiovascular Disease, Diabetes, and Beyond.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Fluorescent labeling of biocompatible block copolymers: synthetic strategies and applications in bioimaging.Materials advances · 2021Review
- High efficiency loading of micellar nanoparticles with a light switch for enzyme-induced rapid release of cargo.Biomaterials science · 2021Article
- Poly(peptide): Synthesis, Structure, and Function of Peptide-Polymer Amphiphiles and Protein-like Polymers.Accounts of chemical research · 2020Article
- Morphological transformation enhances Tumor Retention by Regulating the Self-assembly of Doxorubicin-peptide Conjugates.Theranostics · 2020Article
- Tumor Retention of Enzyme-Responsive Pt(II) Drug-Loaded Nanoparticles Imaged by Nanoscale Secondary Ion Mass Spectrometry and Fluorescence Microscopy.ACS central science · 2018Article
- Fluorescent ROMP Monomers and Copolymers for Biomedical Applications.Macromolecular chemistry and physics · 2017Article
- Enzyme-Targeted Nanoparticles for Delivery to Ischemic Skeletal Muscle.Polymer chemistry · 2017Article
- What is new in nanoparticle-based photoacoustic imaging?Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- Nanoparticle-based probes to enable noninvasive imaging of proteolytic activity for cancer diagnosis.Nanomedicine (London, England) · 2016Review
- Biosynthetic Polymers as Functional Materials.Macromolecules · 2016Review
- Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer.Biomaterials · 2016Article
- Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species.Chemical communications (Cambridge, England) · 2016Article
- Polycatechol Nanoparticle MRI Contrast Agents.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.Advanced materials (Deerfield Beach, Fla.) · 2015Article
- Dye Encapsulation in Polynorbornene Micelles.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors.Advanced materials (Deerfield Beach, Fla.) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.