SynthesisArchives of orthopaedic and trauma surgery2013
Treatment of acute ankle ligament injuries: a systematic review.
Synthesis in Archives of orthopaedic and trauma surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02609308 (Platelet Rich Plasma and Lateral Ankle Sprain. A Comparative Study), which is not on this map. Cited by 65 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Platelet Rich Plasma and Lateral Ankle Sprain. A Comparative Study
Who cites it
65 citing papers in PubMed, 5 syntheses or guidelines pooled it, 272 citations in OpenAlex.
- Towards the strategies of return to sport after lateral ankle Sprain: a systematic review.Annals of medicine · 2025Pooled it
- Evidence-based clinical practice guidelines for the management of acute ankle injuries according to: a PRISMA systematic review and quality appraisal with AGREE II.BMC musculoskeletal disorders · 2024Pooled it
- Time-loss and recurrence of lateral ligament ankle sprains in male elite football: A systematic review and meta-analysis.Scandinavian journal of medicine & science in sports · 2022Pooled it
- Time-sensitive ambulatory orthopaedic soft-tissue surgery paradigms during the COVID-19 pandemic.International orthopaedics · 2020Pooled it
- What is the quality of clinical practice guidelines for the treatment of acute lateral ankle ligament sprains in adults? A systematic review.BMC musculoskeletal disorders · 2019Pooled it
- Effects of Dangguixu-san in patients with acute lateral ankle sprain: a randomized controlled trial.Trials · 2021Trial
- Should ice application be replaced with neurocryostimulation for the treatment of acute lateral ankle sprains? A randomized clinical trial.Journal of foot and ankle research · 2020Trial
- Add-on effect of kinesiotape in patients with acute lateral ankle sprain: a randomized controlled trial.Trials · 2020Trial
- Repair of only anterior talofibular ligament resulted in similar outcomes to those of repair of both anterior talofibular and calcaneofibular ligaments.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Trial
- Evaluation of the therapeutic effects of led (λ627 ± 10 nm) on the initial phase of ankle sprain treatment: a randomised placebo-controlled clinical trial.Lasers in medical science · 2018Trial
- Randomized comparison of tape versus semi-rigid and versus lace-up ankle support in the treatment of acute lateral ankle ligament injury.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Trial
- Ankle pump exercises do not produce clinically meaningful benefits in oedema, pain, functionality or mobility after acute ankle sprain: a randomised controlled trial.Brazilian journal of physical therapy · 2026Article
- Reconsidering uniform treatment: magnetic resonance imaging-based insights into the multiform pathophysiology of sprained ankles.BMC musculoskeletal disorders · 2026Article
- Temporal changes in the talofibular distance during ultrasound-guided anterior drawer testing in grade III lateral ankle sprains: a retrospective observational study.Journal of medical ultrasonics (2001) · 2026Article
- Development and validation of a novel approach for quantifying dimensions of the lateral ligaments in human ankle dissections.Journal of anatomy · 2026Article
- Differences in neuromuscular function of the ankle joint following lateral ankle sprain between copers and cai individuals: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2026Article
- Clinical assessment of lateral ankle sprains among Swedish physiotherapists: a nationwide survey comparing practice to international and locally modified frameworks.BMC sports science, medicine & rehabilitation · 2026Article
- The effects of pulsed electromagnetic field therapy on pain and physical functions in patients with soft tissue injuries: a systematic review of randomised controlled trials.Frontiers in sports and active living · 2026Review
- Platelet-rich plasma and hyaluronic acid in the treatment of acute ankle sprains: A review.Biomolecules & biomedicine · 2025Review
- [Online resources for ankle sprains : A German language web analysis].Unfallchirurgie (Heidelberg, Germany) · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLateral ankle sprains are common musculoskeletal injuries.
objectivesThe objective of this study was to perform a systematic literature review of the last 10 years regarding evidence for the treatment and prevention of lateral ankle sprains. DATA SOURCE: Pubmed central, Google scholar. STUDY ELIGIBILITY CRITERIA: Meta-analysis, prospective randomized trials, English language articles.
interventionsSurgical and non-surgical treatment, immobilization versus functional treatment, different external supports, balance training for rehabilitation, balance training for prevention, braces for prevention.
methodsA systematic search for articles about the treatment of lateral ankle sprains that were published between January 2002 and December 2012.
resultsThree meta-analysis and 19 articles reporting 16 prospective randomized trials could be identified. The main advantage of surgical ankle ligament repair is that objective instability and recurrence rate is less common when compared with non-operative treatment. Balancing the advantages and disadvantages of surgical and non-surgical treatment, we conclude that the majority of grades I, II and III lateral ankle ligament ruptures can be managed without surgery. For non-surgical treatment, long-term immobilization should be avoided. For grade III injuries, however, a short period of immobilization (max. 10 days) in a below knee cast was shown to be advantageous. After this phase, the ankle is most effectively protected against inversion by a semi-rigid ankle brace. Even grades I and II injuries are most effectively treated with a semi-rigid ankle brace. There is evidence that treatment of acute ankle sprains should be supported by a neuromuscular training. Balance training is also effective for the prevention of ankle sprains in athletes with the previous sprains. There is good evidence from high level randomized trials in the literature that the use of a brace is effective for the prevention of ankle sprains.
conclusionBalancing the advantages and disadvantages of surgical and non-surgical treatment, we conclude that the majority of grades I, II and III lateral ankle ligament ruptures can be managed without surgery. The indication for surgical repair should be always made on an individual basis. This systematic review supports a phase adapted non-surgical treatment of acute ankle sprains with a short-term immobilization for grade III injuries followed by a semi-rigid brace. More prospective randomized studies with a longer follow-up are needed to find out what type of non-surgical treatment has the lowest re-sprain rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.