ArticleMammalian genome : official journal of the International Mammalian Genome Society2013
High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Therapeutic Effects and Mechanisms of Fucoidan on Dyslipidemia in Obese Mice.Food science & nutrition · 2026Article
- Repairing Atp10D in C57Bl/6J mice restores protein expression but does not mitigate metabolic stress from high fat diet.Scientific reports · 2026Article
- Article
- Effects of crowberry (Food & nutrition research · 2026Article
- Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome.Handbook of experimental pharmacology · 2026Review
- Impact of olive oil and different animal fats on tissue lipid profiles of C57PL/6N mice fed non-atherogenic diet.Scientific reports · 2025Article
- Butyrate improves testicular spermatogenic dysfunction induced by a high-fat diet.Translational andrology and urology · 2025Article
- Protein restriction associated with high fat induces metabolic dysregulation without obesity in juvenile mice.Nutrition & metabolism · 2024Article
- Article
- Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice.Aging and disease · 2024Article
- Antidiabetic and Antihyperlipidemic Activities and Molecular Mechanisms ofCurrent issues in molecular biology · 2024Article
- Single-cell RNA sequencing reveals the effects of high-fat diet on oocyte and early embryo development in female mice.Reproductive biology and endocrinology : RB&E · 2024Article
- Silicon as a Functional Meat Ingredient Improves Jejunal and Hepatic Cholesterol Homeostasis in a Late-Stage Type 2 Diabetes Mellitus Rat Model.Foods (Basel, Switzerland) · 2024Article
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- Association of a high-fat diet with I-FABP as a biomarker of intestinal barrier dysfunction driven by metabolic changes in Wistar rats.Lipids in health and disease · 2023Article
- Progesterone Has No Impact on the Beneficial Effects of Estradiol Treatment in High-Fat-Fed Ovariectomized Mice.Current issues in molecular biology · 2023Article
- (Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet-Induced Hepatic Steatosis.Biomolecules · 2023Article
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Authors and funding
11 authors.
Funding
Abstract
C57BL/6N (B6N) is becoming the standard background for genetic manipulation of the mouse genome. The B6N, whose genome is very closely related to the reference C57BL/6J genome, is versatile in a wide range of phenotyping and experimental settings and large repositories of B6N ES cells have been developed. Here, we present a series of studies showing the baseline characteristics of B6N fed a high-fat diet (HFD) for up to 12 weeks. We show that HFD-fed B6N mice show increased weight gain, fat mass, and hypercholesterolemia compared to control diet-fed mice. In addition, HFD-fed B6N mice display a rapid onset of lipid accumulation in the liver with both macro- and microvacuolation, which became more severe with increasing duration of HFD. Our results suggest that the B6N mouse strain is a versatile background for studying diet-induced metabolic syndrome and may also represent a model for early nonalcoholic fatty liver disease.
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