ArticleLasers in medical science2014
Pulsed 808-nm infrared laser stimulation of the auditory nerve in guinea pig cochlea.
Article in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Photobiomodulation with near-infrared laser for tinnitus management: preliminary animal experiments and randomized clinical trials.Lasers in medical science · 2024Trial
- Two-photon imaging of excitatory and inhibitory neural response to infrared neural stimulation.Neurophotonics · 2024Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus.Scientific reports · 2023Article
- Inhibitory effect of 980-nm laser on neural activity of the rat's cochlear nucleus.Neurophotonics · 2019Article
- Short-wavelength infrared laser activates the auditory neurons: comparing the effect of 980 vs. 810 nm wavelength.Lasers in medical science · 2017Article
- Effect of shorter pulse duration in cochlear neural activation with an 810-nm near-infrared laser.Lasers in medical science · 2017Article
- Optoacoustic effect is responsible for laser-induced cochlear responses.Scientific reports · 2016Article
- A contrastive analysis of laser heating between the human and guinea pig cochlea by numerical simulations.Biomedical engineering online · 2016Article
- Pulsed 980 nm short wavelength infrared neural stimulation in cochlea and laser parameter effects on auditory response characteristics.Biomedical engineering online · 2015Article
- Performance analysis of the beam shaping method on optical auditory neural stimulation in vivo.Lasers in medical science · 2015Article
- Attenuated infrared neuron stimulation response in cochlea of deaf animals may associate with the degeneration of spiral ganglion neurons.Biomedical optics express · 2015Article
- Effects of heat conduction on the spatial selectivity of infrared stimulation in the cochlea.Biomedical engineering online · 2015Article
- Optical Stimulation of Neurons.Current molecular imaging · 2014Article
- Photons and neurons.Hearing research · 2014Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulsed near-infrared radiation has been proposed as an alternative stimulus for auditory nerve stimulation and could be potentially used in the design of cochlear implant. Although the infrared with high absorption coefficient of water (i.e., wavelength ranged from 1.8 to 2.2 μm) has been widely investigated, the lymph in the cochlea absorbs most of the infrared energies, and only a small part can arrive at the target auditory nerves. The present study is aimed to test whether the short-wavelength near-infrared irradiation with lower absorption coefficients can penetrate the lymph fluid to stimulate the auditory nerves. An 808-nm near-infrared laser was chosen to stimulate the auditory nerve in the guinea pig cochlea. The infrared pulse was delivered by an optical fiber that was surgically inserted near the round window membrane and oriented toward the spiral ganglion cells in the basal turn of the cochlea. The 2-Hz infrared pulses were used to stimulate the cochlea before and after the deafness with different pulse durations (100-1,000 μs). Optically evoked compound action potentials (oCAPs) were recorded during the infrared radiation. We successfully recorded oCAPs from both normal hearing animals and deafened animals. The oCAP amplitude increased with the infrared radiation energy. The preliminary experiment suggests that the near-infrared with lower absorption coefficients can effectively pass through the lymph filled in the cochlea and stimulate the auditory nerve. Further studies will optimize the deafness animal model and determine the optimal stimulation parameters.
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