ArticleMolecular systems biology2013
The Neurospora photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation.
Article in Molecular systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- The photolyase/cryptochrome of Aspergillus nidulans senses oxidative stress and shuttles from nuclei to mitochondria.Nature communications · 2026Article
- Transcription activator WCC recruits deacetylase HDA3 to control transcription dynamics and bursting inScience advances · 2023Article
- Data-driven modelling captures dynamics of the circadian clock of Neurospora crassa.PLoS computational biology · 2022Article
- The Resonance and Adaptation ofJournal of fungi (Basel, Switzerland) · 2021Article
- A light life together: photosensing in the plant microbiota.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021Review
- A Mathematical Model to Characterize the Role of Light Adaptation in Mammalian Circadian Clock.Frontiers in molecular biosciences · 2021Article
- Article
- The wheat pathogen Zymoseptoria tritici senses and responds to different wavelengths of light.BMC genomics · 2020Article
- Modeling Reveals a Key Mechanism for Light-Dependent Phase Shifts of Neurospora Circadian Rhythms.Biophysical journal · 2018Article
- Light induces oxidative damage and protein stability in the fungal photoreceptor Vivid.PloS one · 2018Article
- Fungal photobiology: visible light as a signal for stress, space and time.Current genetics · 2015Review
- Article
- Short LOV Proteins in Methylocystis Reveal Insight into LOV Domain Photocycle Mechanisms.PloS one · 2015Article
- Genome-wide characterization of light-regulated genes in Neurospora crassa.G3 (Bethesda, Md.) · 2014Article
- It is not the parts, but how they interact that determines the behaviour of circadian rhythms across scales and organisms.Interface focus · 2014Article
- Targets of light signalling in Trichoderma reesei.BMC genomics · 2013Article
- Light-dependent and circadian transcription dynamics in vivo recorded with a destabilized luciferase reporter in Neurospora.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The light response in Neurospora is mediated by the photoreceptor and circadian transcription factor White Collar Complex (WCC). The expression rate of the WCC target genes adapts in daylight and remains refractory to moonlight, despite the extraordinary light sensitivity of the WCC. To explain this photoadaptation, feedback inhibition by the WCC interaction partner VIVID (VVD) has been invoked. Here we show through data-driven mathematical modeling that VVD allows Neurospora to detect relative changes in light intensity. To achieve this behavior, VVD acts as an inhibitor of WCC-driven gene expression and, at the same time, as a positive regulator that maintains the responsiveness of the photosystem. Our data indicate that this paradoxical function is realized by a futile cycle that involves the light-induced sequestration of active WCC by VVD and the replenishment of the activatable WCC pool through the decay of the photoactivated state. Our quantitative study uncovers a novel network motif for achieving sensory adaptation and defines a core input module of the circadian clock in Neurospora.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.