ArticleInternational journal of obesity (2005)2014
Piperonal prevents high-fat diet-induced hepatic steatosis and insulin resistance in mice via activation of adiponectin/AMPK pathway.
Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- Recent evidence in support of traditional chinese medicine to restore normal leptin function in simple obesity.Heliyon · 2022Review
- Piperonal synthase from black pepper (Applied biological chemistry · 2022Article
- The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Treatment of Diabetic Mice with a Combination of Ketogenic Diet and Aerobic Exercise via Modulations of PPARs Gene Programs.PPAR research · 2018Article
- Antiobesity potential of Piperonal: promising modulation of body composition, lipid profiles and obesogenic marker expression in HFD-induced obese rats.Nutrition & metabolism · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePiperonal is an important flavor additive with antibacterial and anxiolytic properties. We investigated the effects and possible mechanisms of piperonal protection against high-fat diet (HFD)-induced hepatic steatosis and insulin resistance.
methodsC57BL/6 J mice were fed with a normal diet (ND; based on the AIN-76 rodent diet), HFD (20% fat and 1% cholesterol), or piperonal-supplemented diet (POD; HFD supplemented with 0.05% piperonal) for 10 weeks.
resultsPiperonal supplementation reduced hepatic lipid concentrations, liver dysfunction and plasma levels of insulin and glucose in HFD-fed mice. Piperonal significantly enhanced mRNA expression and secretion of adiponectin in 3T3-L1 adipocytes. Dietary piperonal significantly increased circulating adiponectin levels and hepatic AMP-activated protein kinase (AMPK) activation in HFD-fed mice; these were associated with the suppression of sterol regulatory element binding protein-1c and activation of glucose transporter-2 translocation in the livers. Piperonal also significantly reduced the expression of endoplasmic reticulum (ER) stress markers in the livers of HFD-fed mice.
conclusionsPiperonal may activate the adiponectin/AMPK pathway in the livers of mice. The activated adiponectin/AMPK axis may inhibit p70S6 kinase signaling and the ER stress response, with protective effects on hepatic steatosis and insulin resistance.
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