Evidence map›Paper›PMID 23711638›Full record

ArticlePain2013

Neonatal pain-related stress, functional cortical activity and visual-perceptual abilities in school-age children born at extremely low gestational age.

Sam M Doesburg, Cecil M Chau, Teresa P L Cheung, Alexander Moiseev, Urs Ribary, Anthony T Herdman, Steven P Miller, Ivan L Cepeda, Anne Synnes, Ruth E Grunau

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05444608 (Evaluation of the Effect of Use of Breast Milk Odor and White Noise on Pain Management During Heel Lance in Premature Newborns), which is not on this map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
33.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05444608 nacompletednot on this mapstarted 2022, after this paper: background citation

Evaluation of the Effect of Use of Breast Milk Odor and White Noise on Pain Management During Heel Lance in Premature Newborns: A Randomized Controlled Study

TypeinterventionalSponsorAnkara UniversityRan2022 to 2022Enrolled66ConditionsPainArmsBreast milk olfactory stimulation, White noise auditory stimulation
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 274 citations in OpenAlex.

  1. Venepuncture versus heel lance for blood sampling in term neonates.The Cochrane database of systematic reviews · 2026
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  10. Transcutaneous bilirubin measurements in preterm infants: the impact of race, age, and phototherapy.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  11. Cumulative exposure to opioids and benzodiazepines in extremely preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2026
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sam M DoesburgDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada Program in Neurosciences and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada Department of Medical Imaging, University of Toronto, Toronto, ON, Canada Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, BC, Canada Department of Physics, Simon Fraser University, Burnaby, BC, Canada Down Syndrome Research Foundation, Burnaby, BC, Canada Department of Psychology, Simon Fraser University, Burnaby, BC, Canada Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada Department of Audiology and Speech Sciences, University of British Columbia, Vancouver, BC, Canada Department of Neurology, The Hospital for Sick Children Research Institute, Toronto, ON, Canada Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
Cecil M Chau
Teresa P L Cheung
Alexander Moiseev
Urs Ribary
Anthony T Herdman
Steven P Miller
Ivan L Cepeda
Anne Synnes
Ruth E Grunau
Child and Family Research Institute · CAUniversity of British Columbia · CAUniversity of Toronto · CADown Syndrome Research Foundation · CA

Funding

PAIN IN PRETERM INFANTS--DEVELOPMENT AND EFFECTSR01HD039783 · NICHD · UNIVERSITY OF BRITISH COLUMBIA · PI GRUNAU, RUTH E · 2001 to 2012
$1.8M
NICHD NIH HHS R01 HD039783
6 · The paper itself

Abstract

Children born very prematurely (< or =32 weeks) often exhibit visual-perceptual difficulties at school-age, even in the absence of major neurological impairment. The alterations in functional brain activity that give rise to such problems, as well as the relationship between adverse neonatal experience and neurodevelopment, remain poorly understood. Repeated procedural pain-related stress during neonatal intensive care has been proposed to contribute to altered neurocognitive development in these children. Due to critical periods in the development of thalamocortical systems, the immature brain of infants born at extremely low gestational age (ELGA; < or =28 weeks) may have heightened vulnerability to neonatal pain. In a cohort of school-age children followed since birth we assessed relations between functional brain activity measured using magnetoencephalogragy (MEG), visual-perceptual abilities and cumulative neonatal pain. We demonstrated alterations in the spectral structure of spontaneous cortical oscillatory activity in ELGA children at school-age. Cumulative neonatal pain-related stress was associated with changes in background cortical rhythmicity in these children, and these alterations in spontaneous brain oscillations were negatively correlated with visual-perceptual abilities at school-age, and were not driven by potentially confounding neonatal variables. These findings provide the first evidence linking neonatal pain-related stress, the development of functional brain activity, and school-age cognitive outcome in these vulnerable children.

Indexed as

Gestational AgeChildFemaleHumansInfant, Extremely Low Birth WeightInfant, Extremely PrematureInfant, NewbornInfant, PrematureLongitudinal StudiesMagnetoencephalographyMalePainPain MeasurementPopulationPregnancyStress, PsychologicalChild developmentCognitionCognitive outcomeDevelopmentMagnetoencephalographyNeonatal painNeural oscillationPainPerceptionPrematurityPretermResting-stateSpontaneous brain activityVisual perception

Identifiers

PMID23711638
PMCPMC3778166
OpenAlexW2024707937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.