ArticleThe American journal of gastroenterology2013
Defining the accuracy of secretin pancreatic function testing in patients with suspected early chronic pancreatitis.
Article in The American journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Nutritional Considerations in Pediatric Pancreatitis: A Position Paper from the NASPGHAN Pancreas Committee and ESPGHAN Cystic Fibrosis/Pancreas Working Group.Journal of pediatric gastroenterology and nutrition · 2018Guideline
- Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]Guideline
- EUS pancreatic function testing and dynamic pancreatic duct evaluation for the diagnosis of exocrine pancreatic insufficiency and chronic pancreatitis.Gastrointestinal endoscopy · 2021Trial
- From bench to bedside: pancreatic juice as a platform for biomarker discovery in pancreatic disease.The Korean journal of internal medicine · 2026Review
- Accuracy of a novel noninvasive secretin-enhanced MRCP severity index scoring system for diagnosis of chronic pancreatitis: correlation with EUS-based Rosemont criteria.La Radiologia medica · 2020Article
- Evaluation and Management of Suspected Early Chronic Pancreatitis (ECP).Current gastroenterology reports · 2020Review
- Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function.Journal of clinical medicine · 2020Article
- Rational Use of Pancreatic Enzymes for Pancreatic Insufficiency and Pancreatic Pain.Advances in experimental medicine and biology · 2019Review
- Exocrine Pancreatic Insufficiency and Malnutrition in Chronic Pancreatitis: Identification, Treatment, and Consequences.Pancreas · 2018Article
- Managing chronic pancreatitis: the view from medical pancreatology.The American journal of gastroenterology · 2018Article
- Chronic Pancreatitis: What the Clinician Wants to Know from MR Imaging.Magnetic resonance imaging clinics of North America · 2018Review
- Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging.European radiology · 2018Article
- Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment.Digestive diseases and sciences · 2017Review
- Pancreatic Disorders.Pediatric clinics of North America · 2017Review
- Potential for Screening for Pancreatic Exocrine Insufficiency Using the Fecal Elastase-1 Test.Digestive diseases and sciences · 2017Review
- Article
- Endoscopic Pancreas Fluid Collection: Methods and Relevance for Clinical Care and Translational Science.The American journal of gastroenterology · 2016Review
- Article
- Pancreatic juice prostaglandin e2 concentrations are elevated in chronic pancreatitis and improve detection of early disease.Clinical and translational gastroenterology · 2015Article
- EUS and secretin endoscopic pancreatic function test predict evolution to overt structural changes of chronic pancreatitis in patients with nondiagnostic baseline imaging.Endoscopic ultrasoundArticle
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Authors and funding
11 authors.
Funding
Abstract
objectivesThe diagnosis of chronic pancreatitis in patients with characteristic symptoms but normal pancreatic imaging is challenging. Assessment of pancreatic function through secretin pancreatic function testing (SPFT) has been advocated in this setting, but its diagnostic accuracy is not fully known.
methodsThis was a retrospective review of patients who received SPFT at our tertiary care institution between January 1995 and December 2008 for suspected chronic pancreatitis. For all patients, medical records were reviewed for evidence of subsequent development of chronic pancreatitis by imaging and/or pathology. Patients were then categorized as "true positive" or "true negative" for chronic pancreatitis based on follow-up imaging or histologic evidence.
resultsIn all, 116 patients underwent SPFT. Of the 27 patients who tested positive, 7 were lost to follow-up. Of the remaining 20 SPFT-positive patients, 9 (45%) developed radiologic or histologic evidence of chronic pancreatitis after a median of 4 years (1-11 years). Of the 89 patients who had negative SPFT testing, 19 were lost to follow-up. Of the remaining 70 patients, 2 were eventually diagnosed with chronic pancreatitis based on subsequent imaging/histology after a median follow-up period of 7 years (3-11 years). The sensitivity of the SPFT in diagnosing chronic pancreatitis was 82% with a specificity of 86%. The positive predictive value (PPV) of chronic pancreatitis was 45% with a negative predictive value (NPV) of 97%.
conclusionsIn patients with suspected early chronic pancreatitis and normal pancreatic imaging, SPFT is highly accurate at ruling out early chronic pancreatitis with a NPV of 97%.
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