ArticlePhotochemistry and photobiology
Protective effect of tropical highland blackberry juice (Rubus adenotrichos Schltdl.) against UVB-mediated damage in human epidermal keratinocytes and in a reconstituted skin equivalent model.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Exploring the Potential of Anthocyanins for Repairing Photoaged Skin: A Comprehensive Review.Foods (Basel, Switzerland) · 2024Review
- StrawberryMolecules (Basel, Switzerland) · 2023Article
- A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders.Antioxidants (Basel, Switzerland) · 2020Review
- Article
- Whole Fruit Phytochemicals Combating Skin Damage and Carcinogenesis.Translational oncology · 2020Review
- Fermentation of Blackberry withNutrients · 2019Article
- Article
- Protective effects of novel derivatives of vitamin DRedox biology · 2019Article
- Red Raspberry Extract Protects the Skin against UVB-Induced Damage with Antioxidative and Anti-inflammatory Properties.Oxidative medicine and cellular longevity · 2019Article
- An Antioxidant Potential, Quantum-Chemical and Molecular Docking Study of the Major Chemical Constituents Present in the Leaves ofPharmaceuticals (Basel, Switzerland) · 2018Article
- Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1).Journal of virological methods · 2018Article
- Role of Ultraviolet Radiation in Papillomavirus-Induced Disease.PLoS pathogens · 2016Article
- The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders.International journal of molecular sciences · 2016Review
- Article
- Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis.Skin pharmacology and physiology · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Solar ultraviolet (UV) radiation, particularly its UVB (280-320 nm) spectrum, is the primary environmental stimulus leading to skin carcinogenesis. Several botanical species with antioxidant properties have shown photochemopreventive effects against UVB damage. Costa Rica's tropical highland blackberry (Rubus adenotrichos) contains important levels of phenolic compounds, mainly ellagitannins and anthocyanins, with strong antioxidant properties. In this study, we examined the photochemopreventive effect of R. adenotrichos blackberry juice (BBJ) on UVB-mediated responses in human epidermal keratinocytes and in a three-dimensional (3D) reconstituted normal human skin equivalent (SE). Pretreatment (2 h) and posttreatment (24 h) of normal human epidermal keratinocytes (NHEKs) with BBJ reduced UVB (25 mJ cm(-2))-mediated (1) cyclobutane pyrimidine dimers (CPDs) and (2) 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) formation. Furthermore, treatment of NHEKs with BBJ increased UVB-mediated (1) poly(ADP-ribose) polymerase cleavage and (2) activation of caspases 3, 8 and 9. Thus, BBJ seems to alleviate UVB-induced effects by reducing DNA damage and increasing apoptosis of damaged cells. To establish the in vivo significance of these findings to human skin, immunohistochemistry studies were performed in a 3D SE model, where BBJ was also found to decrease CPDs formation. These data suggest that BBJ may be developed as an agent to ameliorate UV-induced skin damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.