ArticleGenome biology2013
Mutations within lncRNAs are effectively selected against in fruitfly but not in human.
Article in Genome biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 66 citations in OpenAlex.
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- Selection on synonymous sites: the unwanted transcript hypothesis.Nature reviews. Genetics · 2024Review
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- A model for cis-regulation of transcriptional condensates and gene expression by proximal lncRNAs.Biophysical journal · 2023Article
- Chance promoter activities illuminate the origins of eukaryotic intergenic transcriptions.Nature communications · 2023Article
- The activity of human enhancers is modulated by the splicing of their associated lncRNAs.PLoS computational biology · 2022Article
- Human A-to-I RNA editing SNP loci are enriched in GWAS signals for autoimmune diseases and under balancing selection.Genome biology · 2020Article
- Reverse-genetics studies of lncRNAs-what we have learnt and paths forward.Genome biology · 2020Review
- A Depletion of Stop Codons in lincRNA is Owing to Transfer of Selective Constraint from Coding Sequences.Molecular biology and evolution · 2020Article
- Long non-coding RNAs in development and disease: conservation to mechanisms.The Journal of pathology · 2020Review
- Comparative Transcriptomics Analyses across Species, Organs, and Developmental Stages Reveal Functionally Constrained lncRNAs.Molecular biology and evolution · 2020Article
- Conservation of gene architecture and domains amidst sequence divergence in theJournal of genetics · 2020Article
- Article
- Conserved regions in long non-coding RNAs contain abundant translation and protein-RNA interaction signatures.NAR genomics and bioinformatics · 2019Article
- SSS-test: a novel test for detecting positive selection on RNA secondary structure.BMC bioinformatics · 2019Article
- Ancient exapted transposable elements promote nuclear enrichment of human long noncoding RNAs.Genome research · 2019Article
- Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review.Journal of animal science and technology · 2018Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious studies in Drosophila and mammals have revealed levels of long non-coding RNAs (lncRNAs) sequence conservation that are intermediate between neutrally evolving and protein-coding sequence. These analyses compared conservation between species that diverged up to 75 million years ago. However, analysis of sequence polymorphisms within a species' population can provide an understanding of essentially contemporaneous selective constraints that are acting on lncRNAs and can quantify the deleterious effect of mutations occurring within these loci.
resultsWe took advantage of polymorphisms derived from the genome sequences of 163 Drosophila melanogaster strains and 174 human individuals to calculate the distribution of fitness effects of single nucleotide polymorphisms occurring within intergenic lncRNAs and compared this to distributions for SNPs present within putatively neutral or protein-coding sequences. Our observations show that in D.melanogaster there is a significant excess of rare frequency variants within intergenic lncRNAs relative to neutrally evolving sequences, whereas selection on human intergenic lncRNAs appears to be effectively neutral. Approximately 30% of mutations within these fruitfly lncRNAs are estimated as being weakly deleterious.
conclusionsThese contrasting results can be attributed to the large difference in effective population sizes between the two species. Our results suggest that while the sequences of lncRNAs will be well conserved across insect species, such loci in mammals will accumulate greater proportions of deleterious changes through genetic drift.
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