ArticleBMC infectious diseases2013
Patterns of syphilis testing in a large cohort of HIV patients in Ontario, Canada, 2000-2009.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Routinized Syphilis Screening Among Men Living With Human Immunodeficiency Virus: A Stepped Wedge Cluster Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Demographic, risk factors and motivations among blood donors with reactive serologic tests for syphilis in São Paulo, Brazil.Transfusion medicine (Oxford, England) · 2014Trial
- Successful Scale-up of Syphilis Testing Linked to Routine HIV Viral Load Monitoring in British Columbia.Open forum infectious diseases · 2026Article
- Community and Health Care Provider Preferences for Bacterial Sexually Transmitted Infection Testing Interventions for Gay, Bisexual, and Other Men Who Have Sex With Men: e-Delphi Study.Journal of medical Internet research · 2023Article
- Patient perspectives on the implementation of routinised syphilis screening with HIV viral load testing: Qualitative process evaluation of the Enhanced Syphilis Screening Among HIV-positive Men trial.BMC health services research · 2021Article
- Community-Directed Bacterial Sexually Transmitted Infection Testing Interventions Among Men Who Have Sex With Men: Protocol for an E-Delphi Study in Toronto, Canada.JMIR research protocols · 2019Article
- Reverse syphilis screening algorithm fails to demonstrate cost effectiveness in persons living with HIV.International journal of STD & AIDS · 2018Article
- Global challenges in human immunodeficiency virus and syphilis coinfection among men who have sex with men.Expert review of anti-infective therapy · 2016Review
- Enhanced syphilis screening among HIV-positive men (ESSAHM): a study protocol for a clinic-randomized trial with stepped wedge design.Implementation science : IS · 2016Article
- Article
- Diffusion of Newer HIV Prevention Innovations: Variable Practices of Frontline Infectious Diseases Physicians.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- High incidence of diagnosis with syphilis co-infection among men who have sex with men in an HIV cohort in Ontario, Canada.BMC infectious diseases · 2015Article
- Modest rise in chlamydia and gonorrhoea testing did not increase case detection in a clinical HIV cohort in Ontario, Canada.Sexually transmitted infections · 2014Article
- Cost-effectiveness of enhanced syphilis screening among HIV-positive men who have sex with men: a microsimulation model.PloS one · 2014Article
- Screen more or screen more often? Using mathematical models to inform syphilis control strategies.BMC public health · 2013Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundSince 2000, reported syphilis cases increased ten-fold in Canada, particularly among men who have sex with men (MSM) co-infected with HIV. We characterized temporal patterns of of syphilis testing in a large cohort of HIV patients in Ontario, Canada.
methodsWe analyzed data from a multi-site cohort of people in HIV care from 2000 to 2009. Data were obtained from medical charts, interviews and record linkage with the syphilis test database at the Public Health Ontario Laboratories. We estimated the proportion that had syphilis testing at least once per year and the period and annual prevalence of reactive tests.
resultsAmong 4232 participants, the annual proportion tested rose from 2.7% (95%CI 1.9, 3.5) in 2000 to 54.6% (95%CI 52.9, 56.3) in 2009. Testing was most common for participants who were men who have sex with men (MSM), aged <30, recently diagnosed with HIV, were antiretroviral treatment naive, had routine HIV lab testing at least twice in that year, or tested for syphilis in the preceding year. The proportion with at least one reactive test in 2000-09 was 21.0% (95%CI 19.4, 22.7) for MSM, 5.3% (95%CI 3.3, 7.4) for non-MSM males, and 2.6% (95%CI 1.2, 4.0) for women. Among MSM, the annual prevalence of reactive syphilis tests with high RPR titre (≥1:16) peaked at 3.8% in 2009.
conclusionsThe burden of syphilis co-infection rose considerably among HIV-positive MSM, such that by 2009, at least 1 in 5 men had laboratory evidence of current or past infection. Interventions may be needed to boost syphilis testing to achieve goals set by guidelines even in settings with universal health care.
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