ArticleBMC infectious diseases2013
Impact of asymptomatic Plasmodium falciparum parasitemia on the imunohematological indices among school children and adolescents in a rural area highly endemic for malaria in southern Mozambique.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Prevalence and determinants of asymptomatic malaria infection among schoolchildren in Africa: insights from a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Success or failure of critical steps in community case management of malaria with rapid diagnostic tests: a systematic review.Malaria journal · 2014Pooled it
- Asymptomatic Malaria Cases andPathogens (Basel, Switzerland) · 2024Article
- Higher platelet counts and platelet factors are associated with a reduction in Plasmodium falciparum parasite density in young Malian children.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- Absence of Malaria-Associated Coagulopathy in AsymptomaticOpen forum infectious diseases · 2023Article
- Asymptomatic Malaria Infections in the Time of COVID-19 Pandemic: Experience from the Central African Republic.International journal of environmental research and public health · 2022Article
- Prevalence of asymptomatic malaria, submicroscopic parasitaemia and anaemia in Korogwe District, north-eastern Tanzania.Malaria journal · 2021Article
- Prevalence of Asymptomatic Malaria Infections in Seemingly Healthy Children, the Rural Dzanga Sangha Region, Central African Republic.International journal of environmental research and public health · 2021Article
- Microscopic and Submicroscopic Asymptomatic Plasmodium falciparum Infections in Ghanaian Children and Protection against Febrile Malaria.Infection and immunity · 2020Article
- Red blood cell homeostasis in children and adults with and without asymptomatic malaria infection in Burkina Faso.PloS one · 2020Article
- Prevalence of submicroscopic malaria infection in immigrants living in Spain.Malaria journal · 2019Article
- Article
- Malaria prevalence in asymptomatic and symptomatic children in Kiwangwa, Bagamoyo district, Tanzania.Malaria journal · 2017Article
- Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda.Malaria journal · 2016Article
- On-going malaria transmission in The Gambia despite high coverage of control interventions: a nationwide cross-sectional survey.Malaria journal · 2015Article
- Impact of daily cotrimoxazole on clinical malaria and asymptomatic parasitemias in HIV-exposed, uninfected infants.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Observational
- Article
- NOS2 variants reveal a dual genetic control of nitric oxide levels, susceptibility to Plasmodium infection, and cerebral malaria.Infection and immunity · 2014Article
- Increased severity and mortality in adults co-infected with malaria and HIV in Maputo, Mozambique: a prospective cross-sectional study.PloS one · 2014Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsymptomatic Plasmodium falciparum parasitemia (APFP) has been reported to be highly prevalent in Sub-Saharan Africa, a region heavily burdened by malaria, yet, the impact of APFP on the immunological reference values have not yet been established. This study was aimed at i) determine the prevalence of APFP in children and adolescents living in a region highly endemic for malaria in southern Mozambique and its impact on the immuno-hematological indices and ii) determine the factors independently associated with APFP.
methodsA cross sectional study was conducted in a rural area highly endemic for Malaria in southern Mozambique during the dry season. Apparently healthy children and adolescents were selected for the study.
resultsBlood samples were collected from 348 participants. Plasmodium falciparum was detected in 56.5% (194/343) of study subjects. APFP was more frequent in males and was associated with lower values of hemoglobin and platelets measurements. Parasitized and not parasitized individuals were similar in terms of lymphocyte counts, CD4+ and CD8+ T cells counts. Platelet count was the parameter with strongest association with APFP (OR: 0.991, p= 0.000) in children and its performance in guiding clinical suspicion was moderate (AUC: 0.70, p=0.000). Contrarily, in adolescents, the predictive value of platelets counts was low (AUC: 0.55).
conclusionOverall, our finding demonstrated that APFP is highly prevalent in regions endemic for malaria in southern Mozambique and was associated with lower hematological parameters but unaltered lymphocyte counts, CD4+ and CD8+ T cells counts. Platelets count was of moderate performance in guiding clinical suspicion of APFP in children but not in adolescents.
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