Evidence map›Paper›PMID 23710643›Full record

ArticleJournal of periodontal research2014

Periodontitis in pregnant baboons: systemic inflammation and adaptive immune responses and pregnancy outcomes in a baboon model.

J L Ebersole, S C Holt, D Cappelli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Parturition in baboons (PAPIO SPP.).Scientific reports · 2018
    Article
  5. Prenatal and postnatal administration of prebiotics and probiotics.Seminars in fetal & neonatal medicine · 2017
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

J L EbersoleCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA.
S C Holt
D Cappelli
The University of Texas Health Science Center at San Antonio · USUniversity of Kentucky · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
OHPP Oral Health Pilot Program P30GM110788 · NIGMS · UNIVERSITY OF KENTUCKY · PI MILLER, CRAIG S · 2014 to 2018
$5.4M
Periodontitis and Preterm Birth:Nonhuman Primate ModelR01DE013958 · NIDCR · UNIVERSITY OF KENTUCKY · PI EBERSOLE, JEFFREY L · 2002 to 2006
$3.4M
CELLULAR AND MOLECULAR TARGETING OF TMJ DESTRUCTIONR03DE013598 · NIDCR · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI TIPTON, DAVID ALEXANDER · 2001 to 2002
$71k
NIDCR NIH HHS DE013598NIDCR NIH HHS R01 DE013958NIGMS NIH HHS P30 GM110788NIH HHS P51 OD011133PHS HHS 13986
6 · The paper itself

Abstract

BACKGROUND/

objectivesChronic periodontal infections have been suggested to contribute to the risk of adverse pregnancy outcomes. MATERIAL AND

methodsThis study describes the relationship of patterns of systemic inflammatory mediators and IgG antibody to 20 oral bacteria in pregnant female baboons (Papio anubis) coupled with clinical features of ligature-induced periodontitis, as risk indicators for adverse pregnancy outcomes. Animals showing a preterm delivery and/or low birth weight newborns, as well as those pregnancies resulting in spontaneous abortion, stillbirth, or fetal demise were tabulated as adverse pregnancy outcomes.

resultsA significantly greater frequency of the periodontitis group neonates had a low birth weight (18.1%; p = 0.008) and decreased gestational age (9.8%). Spontaneous abortion/stillbirth/fetal demise were increased in the periodontitis (8.7%) versus the control group (3.8%) (p = 0.054). The baseline oral clinical presentation of the experimental animals did not relate to the adverse pregnancy outcomes. Animals with the greatest extent/severity of periodontitis progression during the initial ½ of gestation (ie. to mid-pregnancy) had the greatest risk for adverse pregnancy outcomes. Baseline biological parameters indicating historical responses of the animals to periodontal challenge demonstrated individual variation in selected mediators, some of which became more differential during ligature-induced periodontitis. The relationship of clinical parameters to systemic inflammatory responses was consistent with a temporal contribution to adverse pregnancy outcomes in a subset of the animals.

conclusionsThese results support a link between periodontitis and adverse pregnancy outcomes in the baboons and provide a prospective experimental model for delineating the biologic parameters that contribute to a causal relationship between chronic oral infections and birth events.

Indexed as

Pregnancy OutcomeAbortion, SpontaneousAdaptive ImmunityAnimalsAnimals, NewbornAntibodies, BacterialBacteroidesBirth WeightDisease Models, AnimalFemaleFetal DeathFusobacterium nucleatumGestational AgeGingivitisImmunoglobulin GInflammationAntibodies, BacterialImmunoglobulin GInflammation Mediatorsbaboonsinflammationperiodontitispregnancy

Identifiers

PMID23710643
PMCPMC3969847
OpenAlexW2024175976

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.