ReviewJournal of diabetes research2013
Animal models of GWAS-identified type 2 diabetes genes.
Review in Journal of diabetes research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Cost-effectively dissecting the genetic architecture of complex wool traits in rabbits by low-coverage sequencing.Genetics, selection, evolution : GSE · 2022Article
- Restoration of mRNA Expression of Solute Carrier Proteins in Liver of Diet-Induced Obese Mice by Metformin.Frontiers in endocrinology · 2021Article
- Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research.Frontiers in endocrinology · 2020Review
- Mechanisms of Type 2 Diabetes Risk Loci.Current diabetes reports · 2017Review
- Zinc Transport Gets Its Zing Back: Double-Knockout of ZnT7 and ZnT8 Reveals the Importance of Zinc Transporters to Insulin Secretion.Endocrinology · 2016Article
- Current understanding and dispute on the function of the Wnt signaling pathway effector TCF7L2 in hepatic gluconeogenesis.Genes & diseases · 2016Review
- Genetic and epigenetic modifications in the pathogenesis of diabetic retinopathy: a molecular link to regulate gene expression.New frontiers in ophthalmology (London) · 2016Article
- Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia.Nutrition & metabolism · 2016Article
- Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice.Human molecular genetics · 2015Article
- SLC30A8 mutations in type 2 diabetes.Diabetologia · 2015Review
- LKB1 and AMPK differentially regulate pancreatic β-cell identity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- ADCY5 couples glucose to insulin secretion in human islets.Diabetes · 2014Article
- The pancreatic β cell: recent insights from human genetics.Trends in endocrinology and metabolism: TEM · 2014Article
- Zinc transporter 8 (ZnT8) and β cell function.Trends in endocrinology and metabolism: TEM · 2014Review
- Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Nature genetics · 2014Article
- Zinc transport and diabetes risk.Nature genetics · 2014Article
- TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass.Diabetologia · 2014Article
- Minireview: intraislet regulation of insulin secretion in humans.Molecular endocrinology (Baltimore, Md.) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.