ArticleComputational and mathematical methods in medicine2013
Spatiotemporal quantification of local drug delivery using MRI.
Article in Computational and mathematical methods in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Durability Testing of a Polymer Worm Gear Used in a Vehicle Steering System.Materials (Basel, Switzerland) · 2025Article
- Antimicrobials in polymethylmethacrylate: from prevention to prosthetic joint infection treatment: basic principles and risk of resistance.Arthroplasty (London, England) · 2023Article
- Temperature-responsive PNDJ hydrogels provide high and sustained antimicrobial concentrations in surgical sites.Drug delivery and translational research · 2019Article
- Determination of Tobramycin and Vancomycin Exposure Required to Eradicate Biofilms on Muscle and Bone TissueJournal of bone and joint infection · 2019Article
- Relative diffusion of paramagnetic metal complexes of MRI contrast agents in an isotropic hydrogel medium.Radiological physics and technology · 2017Article
- Local gentamicin delivery from resorbable viscous hydrogels is therapeutically effective.Clinical orthopaedics and related research · 2015Article
- Antimicrobial distribution from local delivery depends on dose : a pilot study with MRI.Clinical orthopaedics and related research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controlled release formulations for local, in vivo drug delivery are of growing interest to device manufacturers, research scientists, and clinicians; however, most research characterizing controlled release formulations occurs in vitro because the spatial and temporal distribution of drug delivery is difficult to measure in vivo. In this work, in vivo magnetic resonance imaging (MRI) of local drug delivery was performed to visualize and quantify the time resolved distribution of MRI contrast agents. Three-dimensional T1 maps (generated from T1-weighted images with varied TR) were processed using noise-reducing filtering. A segmented region of contrast, from a thresholded image, was converted to concentration maps using the equation 1/T1=1/T1,0+R1C, where T1,0 and T1 are the precontrast and postcontrast T1 map values, respectively. In this technique, a uniform estimated value for T 1,0 was used. Error estimations were performed for each step. The practical usefulness of this method was assessed using comparisons between devices located in different locations both with and without contrast. The method using a uniform T1,0, requiring no registration of pre- and postcontrast image volumes, was compared to a method using either affine or deformation registrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.