ArticleEvidence-based complementary and alternative medicine : eCAM2013
Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A Systematic Review of the Biological Effects of Cordycepin.Molecules (Basel, Switzerland) · 2021Pooled it
- Sleep as the Foundation of Brain Health.Seminars in neurology · 2025Review
- Effectiveness of fermentation broth ofFrontiers in neurology · 2025Article
- Article
- Efficacy and Safety ofFrontiers in psychiatry · 2021Article
- A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin.Scientific reports · 2019Article
- Interleukin-4 signalling pathway underlies the anxiolytic effect induced by 3-deoxyadenosine.Psychopharmacology · 2019Article
- Antimicrobial effect and proposed action mechanism of cordycepin against Escherichia coli and Bacillus subtilis.Journal of microbiology (Seoul, Korea) · 2019Article
- Identification of cordycepin biosynthesis-related genes through de novo transcriptome assembly and analysis inRoyal Society open science · 2018Article
- Sleep-Aids Derived from Natural Products.Biomolecules & therapeutics · 2018Review
- 3'-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway.The international journal of neuropsychopharmacology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cordycepin (3'-deoxyadenosine) is a naturally occurring adenosine analogue and one of the bioactive constituents isolated from Cordyceps militaris/Cordyceps sinensis, species of the fungal genus Cordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. Because of similarity of chemical structure of adenosine, cordycepin has been focused on the diverse effects of the central nervous systems (CNSs), like sleep regulation. Therefore, this study was undertaken to know whether cordycepin increases the natural sleep in rats, and its effect is mediated by adenosine receptors (ARs). Sleep was recorded using electroencephalogram (EEG) for 4 hours after oral administration of cordycepin in rats. Sleep architecture and EEG power spectra were analyzed. Cordycepin reduced sleep-wake cycles and increased nonrapid eye movement (NREM) sleep. Interestingly, cordycepin increased θ (theta) waves power density during NREM sleep. In addition, the protein levels of AR subtypes (A1, A2A, and A2B) were increased after the administration of cordycepin, especially in the rat hypothalamus which plays an important role in sleep regulation. Therefore, we suggest that cordycepin increases theta waves power density during NREM sleep via nonspecific AR in rats. In addition, this experiment can provide basic evidence that cordycepin may be helpful for sleep-disturbed subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.