ArticleJournal of allergy2013
Arginine and nitric oxide pathways in obesity-associated asthma.
Article in Journal of allergy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- A Multi-Omics Approach Uncovers Divergent Mechanisms of Asthma in Normal Weight and Obese Children.Metabolites · 2026Article
- Therapeutic Potential of Arginine-Loaded Red Blood Cell Nanovesicles Targeting Obese Asthma.Mediators of inflammation · 2025Article
- Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia.Scientific reports · 2023Article
- Mediterranean Diet and Airway Inflammation in School-Aged Children.Children (Basel, Switzerland) · 2023Article
- Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism.BMJ open respiratory research · 2023Article
- Outdoor particulate matter exposure affects metabolome in chronic obstructive pulmonary disease: Preliminary study.Frontiers in public health · 2023Article
- Differences in L-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea.Respiratory research · 2022Article
- Clinical Characteristics and Management Strategies for Adult Obese Asthma Patients.Journal of asthma and allergy · 2022Review
- Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD.The journal of allergy and clinical immunology. In practice · 2021Review
- Review - Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics.Journal of asthma and allergy · 2021Review
- Article
- Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma.Environment international · 2019Observational
- Late-onset asthma: current perspectives.Journal of asthma and allergy · 2018Review
- Glucagon-like peptide 1: A potential anti-inflammatory pathway in obesity-related asthma.Pharmacology & therapeutics · 2017Review
- Obesity-related, metabolic asthma: a new role for glucagon-like peptide 1 agonists.The Lancet. Respiratory medicine · 2017Review
- Associations of Exhaled Carbon Monoxide and Fractional Exhaled Nitric Oxide with Metabolic Syndrome: A Cohort Study.Scientific reports · 2016Article
- Metabolic Syndrome Is Associated with Increased Oxo-Nitrative Stress and Asthma-Like Changes in Lungs.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a comorbidity that adversely affects asthma severity and control by mechanisms that are not fully understood. This review will discuss evidence supporting a role for nitric oxide (NO) as a potential mechanistic link between obesity and late-onset asthma (>12 years). Several studies have shown that there is an inverse association between increasing body mass index (BMI) and reduced exhaled NO. Newer evidence suggests that a potential explanation for this paradoxical relationship is related to nitric oxide synthase (NOS) uncoupling, which occurs due to an imbalance between L-arginine (NOS substrate) and its endogenous inhibitor, asymmetric di-methyl arginine (ADMA). The review will propose a theoretical framework to understand the relevance of this pathway and how it may differ between early and late-onset obese asthmatics. Finally, the paper will discuss potential new therapeutic approaches, based on these paradigms, for improving the respiratory health of obese subjects with asthma.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.