ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2013
Cryptosporidiosis among children in an endemic semiurban community in southern India: does a protected drinking water source decrease infection?
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Risk factors for Cryptosporidium infection in low and middle income countries: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2018Pooled it
- Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Trial
- Cryptosporidium infection and associated factors among diarrheic children under five years of age in Eastern Ethiopia.PLoS neglected tropical diseases · 2025Article
- Analysing the interlinkage between diarrhoea and drinking water faecal contamination in India.Journal of water and health · 2024Article
- The Gut-Wrenching Effects of Cryptosporidiosis and Giardiasis in Children.Microorganisms · 2023Review
- Prospective Cohort Study of Cryptosporidium Infection and Shedding in Infants and Their Households.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- The curious case of a cryptic Cryptosporidium and a missing dendritic cell subset.Trends in parasitology · 2022Article
- Molecular Epidemiology of Human Cryptosporidiosis in Low- and Middle-Income Countries.Clinical microbiology reviews · 2021Review
- Benefits and Risks of Smallholder Livestock Production on Child Nutrition in Low- and Middle-Income Countries.Frontiers in nutrition · 2021Review
- Prevalence and Correlates ofOpen forum infectious diseases · 2020Article
- A Genetically Tractable, Natural Mouse Model of Cryptosporidiosis Offers Insights into Host Protective Immunity.Cell host & microbe · 2019Article
- Case-Control Study of Cryptosporidium Transmission in Bangladeshi Households.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Epidemiology and Risk Factors for Cryptosporidiosis in Children From 8 Low-income Sites: Results From the MAL-ED Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Estimating Cryptosporidium and Giardia disease burdens for children drinking untreated groundwater in a rural population in India.PLoS neglected tropical diseases · 2018Article
- Natural History of Cryptosporidiosis in a Birth Cohort in Southern India.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Addressing Cryptosporidium Infection among Young Children in Low-Income Settings: The Crucial Role of New and Existing Drugs for Reducing Morbidity and Mortality.PLoS neglected tropical diseases · 2016Article
- Serum Anti-Cryptosporidial gp15 Antibodies in Mothers and Children Less than 2 Years of Age in India.The American journal of tropical medicine and hygiene · 2015Article
- Molecular characterization of Cryptosporidium spp. among children in rural Ghana.PLoS neglected tropical diseases · 2015Article
- A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.The Lancet. Infectious diseases · 2015Review
- Risk factors for cryptosporidiosis among children in a semi urban slum in southern India: a nested case-control study.The American journal of tropical medicine and hygiene · 2014Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundA quasi-experimental study was conducted to determine whether or not a protected water supply (bottled drinking water) could prevent or delay cryptosporidial infections among children residing in an endemic community.
methodsA total of 176 children residing in a semiurban slum area in southern India were enrolled preweaning and received either bottled (n = 90) or municipal (n = 86) drinking water based on residence in specific streets. Weekly surveillance visits were conducted until children reached their second birthday. Stool samples were collected every month and during diarrheal episodes, and were tested for the presence of Cryptosporidium species by polymerase chain reaction. Differences in the incidence of cryptosporidiosis between bottled and municipal water groups were compared using Poisson survival models, and a propensity score model was developed to adjust for the effect of potential confounders.
resultsA total of 186 episodes of cryptosporidiosis, mostly asymptomatic, were observed in 118 (67%) children during the follow-up period at a rate of 0.59 episodes per child-year. Diarrhea associated with Cryptosporidium species tended to be longer in duration and more severe. Stunting at 6 months was associated with a higher risk of cryptosporidiosis (rate ratio [RR] = 1.40; 95% confidence interval [CI], 1.03-1.91). A higher gastrointestinal disease burden was also seen in children with cryptosporidiosis. Drinking bottled water was not associated with a reduced risk of cryptosporidiosis (adjusted RR = 0.86; 95% CI, .60-1.23).
conclusionsThis study documented a high burden of cryptosporidiosis among children in an endemic Indian slum community. The lack of association between drinking bottled water and cryptosporidiosis suggests possible spread from asymptomatically infected individuals involving multiple transmission pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.