ArticleStroke2013
Ambient fine particulate matter alters cerebral hemodynamics in the elderly.
Article in Stroke, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Short-term Exposure to Air Pollution and Ischemic Stroke: A Systematic Review and Meta-analysis.Neurology · 2023Pooled it
- Environmental risk factors for dementia: a systematic review.BMC geriatrics · 2016Pooled it
- Short term exposure to air pollution and stroke: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2015Pooled it
- Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study.Annals of neurology · 2015Trial
- Association Between PMEuropean journal of neurology · 2026Article
- Association between ambient fine particulate matter and hemorrhagic stroke in Yancheng, China.Frontiers in public health · 2026Article
- Air pollution in relation to brain health indicators and global cognitive functioning in people with cardiovascular disorders along the heart-brain axis.Cerebral circulation - cognition and behavior · 2026Article
- Association between residential proximity to major roadways and nonfatal cardiovascular disease in Chinese older adults: a nationwide study.Scientific reports · 2025Article
- Pathways to the Brain: Impact of Fine Particulate Matter Components on the Central Nervous System.Antioxidants (Basel, Switzerland) · 2025Review
- Particulate matter and co-occurring genetic risk induce oxidative stress and cardiac and brain Alzheimer's pathology.Communications biology · 2025Article
- Associations between short-term exposure to fine particulate matter with ischemic stroke mortality and the role of green space: a time-series study in Zibo, China.Journal of global health · 2025Article
- Two-sample mendelian randomization analysis investigates ambient fine particulate matter's impact on cardiovascular disease development.Scientific reports · 2023Article
- Article
- Article
- Ambient Air Pollution and Stroke: An Updated Review.Stroke · 2023Review
- Fine particulate matter exposure aggravates ischemic injury via NLRP3 inflammasome activation and pyroptosis.CNS neuroscience & therapeutics · 2022Article
- High-normal blood pressure (prehypertension) is associated with PMEnvironmental science and pollution research international · 2022Article
- The mitochondria-targeted antioxidant MitoQ attenuated PMRedox biology · 2021Article
- Interactions of particulate matter and pulmonary surfactant: Implications for human health.Advances in colloid and interface science · 2020Review
- Long-term exposure to air pollution and trajectories of cognitive decline among older adults.Neurology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
background and purposeShort-term elevations in fine particulate matter air pollution (PM2.5) are associated with increased risk of acute cerebrovascular events. Evidence from the peripheral circulation suggests that vascular dysfunction may be a central mechanism. However, the effects of PM2.5 on cerebrovascular function and hemodynamics are unknown.
methodsWe used transcranial Doppler ultrasound to measure beat-to-beat blood flow velocity in the middle cerebral artery at rest and in response to changes in end-tidal CO2 (cerebral vasoreactivity) and arterial blood pressure (cerebral autoregulation) in 482 participants from the Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) of Boston study. We used linear mixed effects models with random subject intercepts to evaluate the association between cerebrovascular hemodynamic parameters and mean PM2.5 levels 1 to 28 days earlier adjusting for age, race, medical history, meteorologic covariates, day of week, temporal trends, and season.
resultsAn interquartile range increase (3.0 µg/m(3)) in mean PM2.5 levels during the previous 28 days was associated with an 8.6% (95% confidence interval, 3.7%-13.8%; P<0.001) higher cerebral vascular resistance and a 7.5% (95% confidence interval, 4.2%-10.6%; P<0.001) lower blood flow velocity at rest. Measures of cerebral vasoreactivity and autoregulation were not associated with PM2.5 levels.
conclusionsIn this cohort of community-dwelling seniors, exposure to PM2.5 was associated with higher resting cerebrovascular resistance and lower cerebral blood flow velocity. If replicated, these findings suggest that alterations in cerebrovascular hemodynamics may underlie the increased risk of particle-related acute cerebrovascular events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.